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Key West to Tyler buses

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Trip Overview

The bus between Key West and Tyler takes 38h 16m. The bus runs, on average, 6 times per week from Key West to Tyler. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

38h 16m
Duration
1,545 mi
Distance
$321
Average price
6 times a week
Frequency

Key West to Tyler bus times

Buses run 6 times a week between Key West and Tyler. The service departs Key West at 7:39 AM in the morning, which arrives into Tyler at 20:55:00. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 38h 16m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA38h 16m • 3 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA38h 16m • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA38h 16m • 3 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA38h 16m • 3 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Key West TransitGreyhound USAFlixbus USAGreyhound USA38h 16m • 3 changes

Frequently asked questions

Want to know about travelling from Key West to Tyler? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key West to Tyler.ExpandLaunch map view
  • Distance: 1,544.5 mi
  • Duration: 38h 16m

What companies run services between Key West, FL, USA and Tyler, TX, USA?

You can take a bus from N Roosevelt & 3rd Street to Tyler via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Atlanta Bus Station in around 36h 32m.

Operators