The average bus between Key West and Tyler takes 40h 55m and the fastest bus takes 38h 21m. The bus service runs several times per day from Key West to Tyler. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Key West and Tyler. The earliest departure is at 7:39 AM in the morning, and the last departure from Key West is at 4:15 PM which arrives into Tyler at 10:45 AM. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 40h 55m. The schedules shown below are for the next available departures.
Arrives next day



37h 21m • 3 changes
Arrives +2 days



42h 30m • 3 changes
Arrives next day



37h 21m • 3 changes
Arrives +2 days



42h 30m • 3 changes
Arrives next day



37h 21m • 3 changes
Arrives +2 days



42h 30m • 3 changes
Want to know about travelling from Key West to Tyler? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Key West to Tyler. However, there are services departing from Key West station and arriving at Tyler station via Big Pine Key - Auto Store / NAPA MM30. The journey, including transfers, takes approximately 40h 55m.
Key West to Tyler bus services, operated by Key West Transit, depart from N Roosevelt & 3rd Street station.
Key West to Tyler bus services, operated by Key West Transit, arrive at Tyler station.
The distance between Key West and Tyler is 1,578.4 km. The road distance is 2,489 km.
You can take a bus from N Roosevelt & 3rd Street to Tyler via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Atlanta Bus Station in around 36h 47m.