The average bus between Key West and Manhattan takes 44h 25m and the fastest bus takes 40h 16m. The bus service runs several times per day from Key West to Manhattan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Key West and Manhattan. The earliest departure is at 7:39 AM in the morning, and the last departure from Key West is at 4:15 PM which arrives into Manhattan at 5:40 PM. All services require a transfer at Big Pine Key - Auto Store / NAPA MM30 and take an average of 44h 25m. The schedules shown below are for the next available departures.
Arrives next day



40h 16m • 3 changes
Arrives +2 days



2d 1h • 3 changes
Arrives next day



40h 16m • 3 changes
Arrives +2 days



2d 1h • 3 changes
Arrives next day



40h 16m • 3 changes
Arrives +2 days



2d 1h • 3 changes
Want to know about travelling from Key West to Manhattan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Key West to Manhattan. However, there are services departing from Key West station and arriving at Manhattan station via Big Pine Key - Auto Store / NAPA MM30. The journey, including transfers, takes approximately 44h 25m.
Key West to Manhattan bus services, operated by Key West Transit, depart from N Roosevelt & 3rd Street station.
Key West to Manhattan bus services, operated by Key West Transit, arrive at Port Authority Bus Terminal station.
The distance between Key West and Manhattan is 1,945 km. The road distance is 2,865 km.
You can take a bus from N Roosevelt & 3rd Street to Port Authority Bus Terminal via Big Pine Key - Auto Store / NAPA MM30, Big Pine Key, Miami Airport Station, and Atlanta Bus Station in around 40h 7m.