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Key Largo to Indianapolis buses

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Trip Overview

The average bus between Key Largo and Indianapolis takes 30h 34m and the fastest bus takes 27h 50m. The bus service runs several times per day from Key Largo to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

30h 34m
Duration
1,275 mi
Distance
$283
Average price
Twice daily
Frequency

Key Largo to Indianapolis bus times

Buses run twice daily between Key Largo and Indianapolis. The earliest departure is at 12:55 PM in the afternoon, and the last departure from Key Largo is at 8:00 PM which arrives into Indianapolis at 4:55 AM. All services require a transfer at Miami Airport Station and take an average of 30h 34m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA32h 55m • 2 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA27h 50m • 2 changes
  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA32h 55m • 2 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA27h 50m • 2 changes
  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA32h 55m • 2 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA27h 50m • 2 changes
  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA32h 55m • 2 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA27h 50m • 2 changes
  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA32h 55m • 2 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAGreyhound USA27h 50m • 2 changes
  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA32h 55m • 2 changes

Frequently asked questions

Want to know about travelling from Key Largo to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Key Largo to Indianapolis.ExpandLaunch map view
  • Distance: 1,275.4 mi
  • Duration: 30h 34m

What companies run services between Key Largo, FL, USA and Indianapolis, IN, USA?

You can take a bus from Key Largo Bus Stop to Indianapolis Union Station via Miami Airport Station and Atlanta Bus Station in around 28h 15m.

Operators