The average bus between Key Largo and Indianapolis takes 34h 27m and the fastest bus takes 32h 30m. The bus service runs several times per day from Key Largo to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Key Largo and Indianapolis. The earliest departure is at 12:55 PM in the afternoon, and the last departure from Key Largo is at 8:00 PM which arrives into Indianapolis at 8:25 AM. All services require a transfer at Miami Airport Station and take an average of 34h 27m. The schedules shown below are for the next available departures.
Arrives next day


32h 30m • 2 changes
Arrives +2 days


36h 25m • 2 changes
Arrives next day


32h 30m • 2 changes
Arrives +2 days


36h 25m • 2 changes
Arrives next day


32h 30m • 2 changes
Arrives +2 days


36h 25m • 2 changes
Arrives next day


32h 30m • 2 changes
Arrives +2 days


36h 25m • 2 changes
Want to know about travelling from Key Largo to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Key Largo to Indianapolis. However, there are services departing from Key Largo station and arriving at Indianapolis station via Miami Airport Station station. The journey, including transfers, takes approximately 34h 27m.
Key Largo to Indianapolis bus services, operated by Greyhound USA, depart from Key Largo Bus Stop station.
Key Largo to Indianapolis bus services, operated by Greyhound USA, arrive at Indianapolis station.
Book your Key Largo to Indianapolis bus tickets online with Greyhound USA and Flixbus USA.
The distance between Key Largo and Indianapolis is 1,717.2 km. The road distance is 2,054 km.
You can take a bus from Key Largo Bus Stop to Indianapolis via Miami Airport Station and Atlanta Bus Station in around 27h 20m.