The average bus between Isernia and Rome Termini takes 2h 40m and the fastest bus takes 2h 29m. The bus service runs several times per day from Isernia to Rome Termini. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Isernia and Rome Termini. The earliest departure is at 6:50 AM in the morning, and the last departure from Isernia is at 6:20 PM which arrives into Rome Termini at 8:55 PM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 2h 40m. The schedules shown below are for the next available departures.

2h 40m • 1 change

2h 38m • 1 change

2h 52m • 1 change

2h 40m • 1 change

2h 32m • 1 change

2h 29m • 1 change

2h 58m • 1 change

2h 43m • 1 change

2h 32m • 1 change

2h 48m • 1 change

2h 43m • 1 change

2h 35m • 1 change

2h 32m • 1 change

2h 32m • 1 change

2h 58m • 1 change

2h 32m • 1 change
Want to know about travelling from Isernia to Rome Termini? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Isernia to Rome Termini. However, there are services departing from Isernia station and arriving at Rome Termini station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 2h 40m.
Isernia to Rome Termini bus services, operated by FlixBus, depart from Isernia station.
Isernia to Rome Termini bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
The distance between Isernia and Rome Termini is 147.7 km. The road distance is 177 km.
ATM Azienda di Trasporti Molisana S.p.A. operates a bus from Isernia to Roma, Autostazione Tiburtina 3 times a day. Tickets cost €8–13 and the journey takes 2h 10m. FlixBus also services this route once daily.