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Isernia to Sicily buses

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Trip Overview

The bus between Isernia and Sicily takes 14h 14m. The bus runs, on average, 6 times per week from Isernia to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

14h 14m
Duration
846 km
Distance
€45
Average price
6 times a week
Frequency

Isernia to Sicily bus times

Buses run 6 times a week between Isernia and Sicily. The service departs Isernia at 6:05 PM in the evening, which arrives into Sicily at 08:19:00. All services require a transfer at Caserta Terminal Bus and take an average of 14h 14m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

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    Arrives next day

    FlixBusAutoservizi Salemi SrlAMAT Palermo S.p.A.14h 14m • 2 changes

Departing Friday, November 6, 2026

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    Arrives next day

    FlixBusAutoservizi Salemi SrlAMAT Palermo S.p.A.14h 14m • 2 changes

Departing Saturday, November 7, 2026

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    Arrives next day

    FlixBusAutoservizi Salemi SrlAMAT Palermo S.p.A.14h 15m • 2 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    FlixBusAutoservizi Salemi SrlAMAT Palermo S.p.A.14h 14m • 2 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    FlixBusAutoservizi Salemi SrlAMAT Palermo S.p.A.14h 14m • 2 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    FlixBusAutoservizi Salemi SrlAMAT Palermo S.p.A.14h 14m • 2 changes

Frequently asked questions

Want to know about travelling from Isernia to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Isernia to Sicily.ExpandLaunch map view
  • Distance: 846.2 km
  • Duration: 14h 14m

What companies run services between Isernia, Italy and Sicily, Italy?

You can take a bus from Isernia to Piazza Boiardo via Caserta Terminal Bus, Caserta pzza Garibaldi, Palermo Terminal Bus, and Stazione Centrale Pensilina Esterna in around 12h 27m.

Operators