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Irvine to Duke University buses

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Trip Overview

The average bus between Irvine and Duke University takes 2d 20h and the fastest bus takes 2d 18h. There is at least one bus per day from Irvine to Duke University. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 20h
Duration
2,700 mi
Distance
$587
Average price
Once daily
Frequency

Irvine to Duke University bus times

Buses run once daily between Irvine and Duke University. The earliest departure is at 5:45 AM in the morning, and the last departure from Irvine is at 10:46 PM which arrives into Duke University at 6:12 AM. All services require a transfer at Artic - Dock 4 and take an average of 2d 20h. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

  •  → 

    Arrives +3 days

    OCTAGreyhound USAGreyhound USAGreyhound USAFlixbus USAGoDurham2d 18h • 5 changes
  •  → 

    Arrives +4 days

    OCTAFlixbus USAGreyhound USAGreyhound USAFlixbus USAGoDurham3d 4h • 5 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +3 days

    OCTAGreyhound USAGreyhound USAGreyhound USAFlixbus USAGoDurham2d 18h • 5 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +3 days

    OCTAFlixbus USAGreyhound USAGreyhound USAFlixbus USAGoDurham2d 22h • 5 changes
  •  → 

    Arrives +3 days

    OCTAGreyhound USAGreyhound USAGreyhound USAFlixbus USAGoDurham2d 18h • 5 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +3 days

    OCTAFlixbus USAGreyhound USAGreyhound USAFlixbus USAGoDurham2d 21h • 5 changes
  •  → 

    Arrives +3 days

    OCTAGreyhound USAGreyhound USAGreyhound USAFlixbus USAGoDurham2d 18h • 5 changes

Frequently asked questions

Want to know about travelling from Irvine to Duke University? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Irvine to Duke University.ExpandLaunch map view
  • Distance: 2,700.4 mi
  • Duration: 2d 20h

What companies run services between Irvine, CA, USA and Duke University, NC, USA?

You can take a bus from Main-Harvard to Duke University via Artic - Dock 4, Anaheim Regional Transportation Intermodal Center, Los Angeles Union Station, Dallas Bus Station, Atlanta Bus Station, Durham, Durham Station, and Flowers Dr at Duke Gardens in around 2d 13h.

Operators