There are 6 ways to get from Irvine to Duke University by plane, bus (Greyhound, Flixbus), train, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly John Wayne Airport Orange County to Raleigh-Durham International Airport
best- Fly from John Wayne Airport Orange County (SNA) to Raleigh-Durham International Airport (RDU)plane SNA - RDU
7h 12m$214–844Train to Los Angeles International Airport, fly to Raleigh-Durham International Airport
cheapest- Take the train from Tustin to L.A. Union Stationtrain
- Fly from Los Angeles International Airport (LAX) to Raleigh-Durham International Airport (RDU)plane LAX - RDU
9h 44m$203–352Bus
- Take the bus from Anaheim Regional Transportation Intermodal Center to Los Angeles Union Stationbus
- Take the bus from Los Angeles Union Station to Dallas Bus Stationbus
- Take the bus from Dallas Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Durhambus
2d 12h$477–751Train, bus
- Take the train from Fullerton Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Raleigh Union Stationtrain
- Take the bus from Union Station - Bus Platform A to Chapel Dr at Duke University Rdbus
2d 23h$1,760–2,812Drive 2,485.2 mi
- Drive from Irvine to Duke Universitycar 2,485.2 mi
40h 23m$425–614Fly John Wayne Airport Orange County to Charlotte Douglas International Airport, train
- Fly from John Wayne Airport Orange County (SNA) to Charlotte Douglas International Airport (CLT)plane SNA - CLT
- Take the train from Charlotte Amtrak Station to Durham Amtrak Stationtrain
10h 2m$319–1,088
Irvine to Duke University by bus and foot
Comparing Your Travel Options
The cheapest way to get from Irvine to Duke University is to train and fly which costs $200 - $360 and takes 9h 44m.
The fastest way to get from Irvine to Duke University is to fly which takes 7h 12m and costs $210 - $850.
No, there is no direct bus from Irvine to Duke University. However, there are services departing from Main-Harvard and arriving at Flowers Dr at Duke Gardens via Anaheim Regional Transportation Intermodal Center, Los Angeles Union Station, Dallas Bus Station, Atlanta Bus Station and Durham Station. The journey, including transfers, takes approximately 2 days 12h.
The distance between Irvine and Duke University is 2240 miles. The road distance is 2499.7 miles.
The best way to get from Irvine to Duke University without a car is to bus which takes 2 days 12h and costs $470 - $750.
It takes approximately 7h 12m to get from Irvine to Duke University, including transfers.
Irvine to Duke University bus services, operated by Greyhound USA, depart from Anaheim Regional Transportation Intermodal Center station.
The best way to get from Irvine to Duke University is to fly which takes 7h 12m and costs $210 - $850. Alternatively, you can bus, which costs $470 - $750 and takes 2 days 12h.
Irvine to Duke University bus services, operated by Greyhound USA, arrive at Los Angeles Union Station.
Duke University is 3h ahead of Irvine. It is currently 11:31 AM in Irvine and 2:31 PM in Duke University.
What companies run services between Irvine, CA, USA and Duke University, NC, USA?
Breeze Airways, Southwest Airlines, and three other airlines fly from John Wayne Airport Orange County (SNA) to Raleigh-Durham International Airport (RDU) every 4 hours. Alternatively, you can take a bus from Main-Harvard to Duke University via Artic - Dock 4, Anaheim Regional Transportation Intermodal Center, Los Angeles Union Station, Dallas Bus Station, Atlanta Bus Station, Durham, Durham Station, and Flowers Dr at Duke Gardens in around 2d 12h.
- Website
- delta.com
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Atlanta
- Ave. Duration
- 7h 27m
- When
- Every day
- Estimated price
- $210–850
Flights from Los Angeles International Airport to Raleigh-Durham International Airport
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $150–650
Flights from Los Angeles International Airport to Raleigh-Durham International Airport via Atlanta
- Ave. Duration
- 6h 56m
- When
- Every day
- Estimated price
- $160–650
Flights from Los Angeles International Airport to Raleigh-Durham International Airport via Nashville
- Ave. Duration
- 7h 27m
- When
- Sunday
- Estimated price
- $150–650
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport via Atlanta
- Ave. Duration
- 6h 46m
- When
- Every day
- Estimated price
- $230–1,000
- Website
- aa.com
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 13m
- When
- Every day
- Estimated price
- $210–850
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 8h 16m
- When
- Every day
- Estimated price
- $200–850
Flights from Los Angeles International Airport to Raleigh-Durham International Airport
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $150–650
Flights from Los Angeles International Airport to Raleigh-Durham International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 6h 27m
- When
- Every day
- Estimated price
- $150–650
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport
- Ave. Duration
- 4h 47m
- When
- Every day
- Estimated price
- $230–950
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 14m
- When
- Every day
- Estimated price
- $230–1,000
- Website
- southwest.com
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Dallas
- Ave. Duration
- 6h 25m
- When
- Monday, Thursday, and Friday
- Estimated price
- $210–850
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Austin
- Ave. Duration
- 7h 35m
- When
- Saturday
- Estimated price
- $210–900
Flights from Los Angeles International Airport to Raleigh-Durham International Airport via Nashville
- Ave. Duration
- 7h 5m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- $150–650
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport via Dallas
- Ave. Duration
- 7h
- When
- Sunday
- Estimated price
- $230–1,000
- Website
- united.com
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport via Houston
- Ave. Duration
- 6h 51m
- When
- Every day
- Estimated price
- $210–900
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport via Houston
- Ave. Duration
- 6h 51m
- When
- Every day
- Estimated price
- $240–1,000
Flights from John Wayne Airport Orange County to Charlotte Douglas International Airport via Denver
- Ave. Duration
- 7h 19m
- When
- Every day
- Estimated price
- $230–1,000
- Website
- flybreeze.com
Flights from John Wayne Airport Orange County to Raleigh-Durham International Airport
- Ave. Duration
- 5h 8m
- When
- Thursday and Sunday
- Estimated price
- $250–1,400
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Fullerton Amtrak Station to Chicago Union Station
- Ave. Duration
- 42h 47m
- Frequency
- Once daily
- Estimated price
- $1,200–1,900
- Website
- Amtrak
Train from Chicago Union Station to Raleigh Union Station
- Ave. Duration
- 24h 1m
- Frequency
- Once daily
- Estimated price
- $550–900
- Website
- Amtrak
Train from Charlotte Amtrak Station to Durham Amtrak Station
- Ave. Duration
- 2h 35m
- Frequency
- 5 times a day
- Estimated price
- $80–130
- Website
- Amtrak
- Phone
- (800) 371-LINK (5465)
- Website
- Metrolink Trains
Train from Tustin to L.A. Union Station
- Ave. Duration
- 1h
- Frequency
- Every 3 hours
- Estimated price
- $8–12
- Website
- Metrolink Trains
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Anaheim Regional Transportation Intermodal Center to Los Angeles Union Station
- Ave. Duration
- 35 min
- Frequency
- Every 4 hours
- Estimated price
- $5–8
- Website
- Greyhound
Bus from Los Angeles Union Station to Dallas Bus Station
- Ave. Duration
- 29h 5m
- Frequency
- 4 times a day
- Estimated price
- $260–400
- Website
- Greyhound
Bus from Dallas Bus Station to Atlanta Bus Station
- Ave. Duration
- 18h 5m
- Frequency
- Every 4 hours
- Estimated price
- $150–230
- Website
- Greyhound
Bus from Atlanta Bus Station to Durham
- Ave. Duration
- 8h 20m
- Frequency
- Twice daily
- Estimated price
- $70–110
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Anaheim Regional Transportation Intermodal Center to Los Angeles Union Station
- Ave. Duration
- 35 min
- Frequency
- 4 times a day
- Estimated price
- $4–7
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to Durham
- Ave. Duration
- 7h 10m
- Frequency
- 5 times a day
- Estimated price
- $60–90
- Schedules at
- Flixbus USA
- Phone
- +1 919 485 7433
- customerservice@gotriangle.org
- Website
- gotriangle.org
Bus from Union Station - Bus Platform A to Chapel Dr at Duke University Rd
- Ave. Duration
- 55 min
- Frequency
- Hourly
- Estimated price
- $3
- Website
- gotriangle.org
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Booking & Getting There
Yes, the driving distance between Irvine to Duke University is 2500 miles. It takes approximately 40h 23m to drive from Irvine to Duke University.
There are 404+ hotels available in Duke University.











