The average bus between Hyannis and Chicago takes 29h 7m and the fastest bus takes 23h 25m. The bus service runs several times per day from Hyannis to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Hyannis and Chicago. The earliest departure is at 4:00 AM at night, and the last departure from Hyannis is at 9:00 PM which arrives into Chicago at 6:10 AM. All services require a transfer at Boston, Bus Terminal South Station and take an average of 29h 7m. The schedules shown below are for the next available departures.
Arrives next day


24h 25m • 2 changes
Arrives +2 days


33h 10m • 2 changes
Arrives next day


22h 25m • 2 changes
Arrives +2 days


33h 10m • 2 changes
Arrives next day


22h 25m • 2 changes
Arrives +2 days


33h 10m • 2 changes
Want to know about travelling from Hyannis to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Hyannis to Chicago. However, there are services departing from Hyannis station and arriving at Chicago station via Boston South Buses. The journey, including transfers, takes approximately 29h 7m.
Hyannis to Chicago bus services, operated by Plymouth & Brockton, depart from Hyannis Transportation Center station.
Hyannis to Chicago bus services, operated by Plymouth & Brockton, arrive at Chicago Bus Station.
The distance between Hyannis and Chicago is 1,436.4 km. The road distance is 1,864 km.
You can take a bus from Hyannis Transportation Center to Chicago Bus Station via Boston, Bus Terminal South Station, Boston, and Newark Penn Station in around 25h.