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How to get fromGainesville to Buffaloby plane, bus (Flixbus, Greyhound), bus, train or car

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There are 8 ways to get from Gainesville to Buffalo by plane, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gainesville Regional Airport to Buffalo Niagara International Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Buffalo Niagara International Airport (BUF)plane plane GNV - BUF
    6h 43m
    $236–1,282

  2. Fly Gainesville Regional Airport to Rochester, bus

    cheapest
    1. Fly from Gainesville Regional Airport (GNV) to Rochester (ROC)plane plane GNV - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    9h 10m
    $146–786

  3. Bus

    1. Take the bus from Gainesville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    29h 20m
    $157–315

  4. Bus, train via New York

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    31h 13m
    $214–614

  5. Drive 1,097.3 mi

    1. Drive from Gainesville to Buffalocar car 1,097.3 mi
    18h 46m
    $201–290

  6. Bus to Orlando, fly to Buffalo Niagara International Airport

    1. Take the bus from Gainesville to Orlando RedCoach Stationbus bus
    2. Fly from Orlando (MCO) to Buffalo Niagara International Airport (BUF)plane plane MCO - BUF
    7h 25m
    $229–1,315

  7. Bus to Jacksonville, fly to Buffalo Niagara International Airport

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Buffalo Niagara International Airport (BUF)plane plane JAX - BUF
    9h 13m
    $313–1,704

  8. Bus, train

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Take the train from Jacksonville to Pittsburgh Amtrak Stationtrain train
    3. Take the bus from Pittsburgh to Buffalobus bus
    37h 30m
    $189–754

Gainesville to Buffalo by bus

Calendar7Weekly Buses
Duration29h 20mAverage Duration
Ticket$157Cheapest Price
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Questions & Answers

What companies run services between Gainesville, FL, USA and Buffalo, NY, USA?

Delta and American Airlines fly from Gainesville Regional Airport (GNV) to Buffalo Niagara International Airport (BUF) 5 times a day. Alternatively, you can take a bus from Gainesville to Buffalo, NY via Atlanta Bus Station, Cleveland Bus Station, and Cleveland, OH in around 29h 20m.

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Need to know: Greyhound

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