The average bus between Manlius and Buffalo takes 6h 28m and the fastest bus takes 5h 7m. The bus service runs several times per day from Manlius to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Manlius and Buffalo. The earliest departure is at 7:56 AM in the morning, and the last departure from Manlius is at 6:11 PM which arrives into Buffalo at 4:00 AM. All services require a transfer at A2 and take an average of 6h 28m. The schedules shown below are for the next available departures.


6h 58m • 2 changes


5h 22m • 2 changes


5h 7m • 2 changes


5h 43m • 2 changes


6h 58m • 2 changes


5h 22m • 2 changes


5h 7m • 2 changes


5h 43m • 2 changes


6h 58m • 2 changes


5h 22m • 2 changes


5h 7m • 2 changes


5h 43m • 2 changes
Want to know about travelling from Manlius to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Manlius to Buffalo. However, there are services departing from Manlius station and arriving at Buffalo station via Buffalo. The journey, including transfers, takes approximately 6h 28m.
Manlius to Buffalo bus services, operated by Centro, depart from Syracuse station.
Manlius to Buffalo bus services, operated by Centro, arrive at Buffalo station.
The distance between Manlius and Buffalo is 236.5 km. The road distance is 283 km.
Trailways operates a bus from Syracuse to Buffalo every 4 hours. Tickets cost $28–100 and the journey takes 3h 10m. Two other operators also service this route.