The average bus between Frederick and Indianapolis takes 20h 46m and the fastest bus takes 20h 25m. The bus service runs several times per day from Frederick to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Frederick and Indianapolis. The earliest departure is at 5:55 AM in the morning, and the last departure from Frederick is at 7:35 PM which arrives into Indianapolis at 4:00 PM. All services require a transfer, and take on average 20h 46m. The schedules shown below are for the next available departures.
Arrives next day

21h 5m • 1 change
Arrives next day

20h 25m • 1 change
Arrives next day

21h 5m • 1 change
Arrives next day

20h 25m • 1 change
Arrives next day

21h 5m • 1 change
Arrives next day

20h 25m • 1 change
Arrives next day

21h 5m • 1 change
Arrives next day

20h 25m • 1 change
Arrives next day

21h 5m • 1 change
Arrives next day

20h 25m • 1 change
Want to know about travelling from Frederick to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Frederick to Indianapolis. However, there are services departing from Frederick station and arriving at Indianapolis station via Pittsburgh Intermodal Station station. The journey, including transfers, takes approximately 20h 46m.
Frederick to Indianapolis bus services, operated by Greyhound USA, depart from Frederick Bus Station.
Frederick to Indianapolis bus services, operated by Greyhound USA, arrive at Indianapolis station.
Book your Frederick to Indianapolis bus tickets online with Greyhound USA and Flixbus USA.
The distance between Frederick and Indianapolis is 750.3 km. The road distance is 878 km.
You can take a bus from Frederick Bus Station to Indianapolis via Pittsburgh Intermodal Station in around 12h 30m.