The average bus between Frederick and Amarillo takes 44h 14m and the fastest bus takes 42h 50m. The bus service runs several times per day from Frederick to Amarillo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Frederick and Amarillo. The earliest departure is at 5:55 AM in the morning, and the last departure from Frederick is at 7:35 PM which arrives into Amarillo at 4:30 PM. All services require a transfer at Pittsburgh Intermodal Station and take an average of 44h 14m. The schedules shown below are for the next available departures.
Arrives next day


41h 50m • 2 changes
Arrives +2 days


44h 55m • 2 changes
Arrives next day


41h 50m • 2 changes
Arrives +2 days


44h 55m • 2 changes
Arrives next day


41h 50m • 2 changes
Arrives +2 days


44h 55m • 2 changes
Want to know about travelling from Frederick to Amarillo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Frederick to Amarillo. However, there are services departing from Frederick station and arriving at Amarillo station via Pittsburgh Intermodal Station station. The journey, including transfers, takes approximately 44h 14m.
Frederick to Amarillo bus services, operated by Greyhound USA, depart from Frederick Bus Station.
Frederick to Amarillo bus services, operated by Greyhound USA, arrive at Amarillo Multimodal Transfer Sta station.
Book your Frederick to Amarillo bus tickets online with Greyhound USA.
The distance between Frederick and Amarillo is 2,202.1 km. The road distance is 2,526 km.
You can take a bus from Frederick Bus Station to Amarillo Multimodal Transfer Sta via Pittsburgh Intermodal Station and St Louis Bus Station in around 34h 15m.