The average bus between Florence and Mainz takes 20h 50m and the fastest bus takes 16h 50m. There is at least one bus per day from Florence to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Florence and Mainz. The earliest departure is at 3:25 PM in the afternoon, and the last departure from Florence is at 8:00 PM which arrives into Mainz at 5:30 PM. All services require a transfer, and take on average 20h 50m. The schedules shown below are for the next available departures.
Arrives next day

16h 50m • 1 change
Arrives next day

21h 30m • 1 change
Arrives next day

16h 50m • 1 change
Arrives next day

21h 30m • 1 change
Want to know about travelling from Florence to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Florence to Mainz. However, there are services departing from Florence station and arriving at Mainz station via Frankfurt central train station station. The journey, including transfers, takes approximately 20h 50m.
Florence to Mainz bus services, operated by FlixBus, depart from Florence Villa Constanza Bus Station.
Florence to Mainz bus services, operated by FlixBus, arrive at Frankfurt central train station.
Book your Florence to Mainz bus tickets online with FlixBus.
The distance between Florence and Mainz is 725.7 km. The road distance is 1,091 km.
FlixBus operates a bus from Florence Villa Constanza Bus Station to Frankfurt central train station twice daily. Tickets cost €70–120 and the journey takes 17h 30m.