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Des Moines to Myrtle Beach buses

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Trip Overview

The bus between Des Moines and Myrtle Beach takes 2d 7h. The bus runs, on average, 5 times per week from Des Moines to Myrtle Beach. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 7h
Duration
1,365 mi
Distance
$281
Average price
5 times a week
Frequency

Des Moines to Myrtle Beach bus times

Buses run 5 times a week between Des Moines and Myrtle Beach. The service departs Des Moines at 7:50 AM in the morning, which arrives into Myrtle Beach at 15:50:00. All services require a transfer at Indianapolis Union Station and take an average of 2d 7h. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 7h • 2 changes

Departing Monday, November 16, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 7h • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 7h • 2 changes

Departing Wednesday, November 18, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 7h • 2 changes

Departing Thursday, November 19, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 7h • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to Myrtle Beach? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Myrtle Beach.ExpandLaunch map view
  • Distance: 1,365.1 mi
  • Duration: 2d 7h

What companies run services between Des Moines, IA, USA and Myrtle Beach, SC, USA?

You can take a bus from Des Moines to Myrtle Beach Bus Station via Indianapolis Union Station and Atlanta Bus Station in around 31h 30m.

Operators