The average bus between Denver and St. Louis takes 16h 55m and the fastest bus takes 16h 30m. The bus service runs several times per day from Denver to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Denver and St. Louis. The earliest departure is at 1:20 PM in the afternoon, and the last departure from Denver is at 7:25 PM which arrives into St. Louis at 12:55 PM. All services run direct with no transfers required, and take on average 16h 55m. The schedules shown below are for the next available departures.
Arrives next day
Arrives next day
Arrives next day
Arrives next day
Want to know about travelling from Denver to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
Yes, there is a direct bus departing from Denver station and arriving at St. Louis station. Services depart twice daily, and operate Once daily. The journey takes approximately 16h 55m.
Denver to St. Louis bus services, operated by Greyhound USA, depart from Denver Union Station.
Denver to St. Louis bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Book your Denver to St. Louis bus tickets online with Greyhound USA.
The distance between Denver and St. Louis is 1,279 km. The road distance is 1,388 km.
Greyhound USA operates a bus from Denver Union Station to St Louis Bus Station twice daily. Tickets cost $140–270 and the journey takes 16h 30m.
