Rome2Rio

Niagara Falls to St. Louis buses

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Trip Overview

The average bus between Niagara Falls and St. Louis takes 20h 6m and the fastest bus takes 20h 5m. The bus runs, on average, 6 times per week from Niagara Falls to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

20h 6m
Duration
805 mi
Distance
$157
Average price
6 times a week
Frequency

Niagara Falls to St. Louis bus times

Buses run 6 times a week between Niagara Falls and St. Louis. The earliest departure is at 1:04 PM in the afternoon, and the last departure from Niagara Falls is at 1:09 PM which arrives into St. Louis at 8:15 AM. All services require a transfer at Buffalo and take an average of 20h 6m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

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    Arrives next day

    NFTABarons BusGreyhound USA20h 10m • 2 changes

Departing Monday, November 16, 2026

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    Arrives next day

    NFTABarons BusGreyhound USA20h 5m • 2 changes

Departing Tuesday, November 17, 2026

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    Arrives next day

    NFTABarons BusGreyhound USA20h 5m • 2 changes

Departing Wednesday, November 18, 2026

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    Arrives next day

    NFTABarons BusGreyhound USA20h 5m • 2 changes

Departing Thursday, November 19, 2026

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    Arrives next day

    NFTABarons BusGreyhound USA20h 5m • 2 changes

Departing Friday, November 20, 2026

  •  → 

    Arrives next day

    NFTABarons BusGreyhound USA20h 5m • 2 changes

Frequently asked questions

Want to know about travelling from Niagara Falls to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Niagara Falls to St. Louis.ExpandLaunch map view
  • Distance: 805.1 mi
  • Duration: 20h 6m

What companies run services between Niagara Falls, NY, USA and St. Louis, MO, USA?

You can take a bus from Pine Avenue & Main Street to St Louis Bus Station via Buffalo and Columbus in around 19h 27m.

Operators