Rome2Rio

Chicago to Key West buses

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Trip Overview

The average bus between Chicago and Key West takes 2d 7h and the fastest bus takes 2d 5h. The bus runs, on average, 6 times per week from Chicago to Key West. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 7h
Duration
1,566 mi
Distance
$334
Average price
6 times a week
Frequency

Chicago to Key West bus times

Buses run 6 times a week between Chicago and Key West. The service departs Chicago at 6:10 AM in the morning, which arrives into Key West at 13:02:00. All services require a transfer at Atlanta Bus Station and take an average of 2d 7h. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit2d 5h • 3 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit2d 5h • 3 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit2d 5h • 3 changes

Departing Wednesday, November 18, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USAKey West Transit2d 5h • 3 changes

Frequently asked questions

Want to know about travelling from Chicago to Key West? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Chicago to Key West.ExpandLaunch map view
  • Distance: 1,565.7 mi
  • Duration: 2d 7h

What companies run services between Chicago, IL, USA and Key West, FL, USA?

You can take a bus from Chicago Bus Station to N Roosevelt & 3rd Street via Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 37h 31m.

Operators