Rome2Rio

Chicago to Key Largo buses

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Trip Overview

The average bus between Chicago and Key Largo takes 2d and the fastest bus takes 47h 15m. The bus runs, on average, 6 times per week from Chicago to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d
Duration
1,465 mi
Distance
$315
Average price
6 times a week
Frequency

Chicago to Key Largo bus times

Buses run 6 times a week between Chicago and Key Largo. The service departs Chicago at 6:10 AM in the morning, which arrives into Key Largo at 06:25:00. All services require a transfer at Atlanta Bus Station and take an average of 2d. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA47h 15m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA47h 15m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA47h 15m • 2 changes

Departing Wednesday, November 18, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA47h 15m • 2 changes

Frequently asked questions

Want to know about travelling from Chicago to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Chicago to Key Largo.ExpandLaunch map view
  • Distance: 1,465 mi
  • Duration: 2d

What companies run services between Chicago, IL, USA and Key Largo, FL, USA?

You can take a bus from Chicago Bus Station to Key Largo Bus Stop via Atlanta Bus Station and Miami Airport Station in around 32h 55m.

Operators