Rome2Rio

How to get fromChicago to Key Largoby plane, shuttle, bus (Flixbus, Greyhound), train, bus or car

Find Transport to Key Largo

See all options

There are 8 ways to get from Chicago to Key Largo by plane, shuttle, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Miami International Airport, shuttle

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Miami International Airport (MIA)plane plane ORD - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    7h 14m
    $142–465

  2. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    32h
    $154–408

  3. Train, bus

    1. Take the train from Chicago Union Station to Hollywood Amtrak Stationtrain train Floridian
    2. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus Greyhound US0720s
    2d 1h
    $383–1,888

  4. Drive 1,371.2 mi

    1. Drive from Chicago to Key Largocar car 1,371.2 mi
    24h 49m
    $251–362

  5. Fly Chicago Midway International Airport to Miami International Airport, shuttle

    1. Fly from Chicago Midway International Airport (MDW) to Miami International Airport (MIA)plane plane MDW - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    6h 46m
    $192–665

  6. Fly Chicago Midway International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Chicago Midway International Airport (MDW) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MDW - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    7h 11m
    $182–535

  7. Fly Chicago O'Hare International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Chicago O'Hare International Airport (ORD) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane ORD - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    7h 38m
    $158–375

  8. Fly Chicago O'Hare International Airport to Key West International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Key West International Airport (EYW)plane plane ORD - EYW
    2. Take the bus from Key West Airport to Key Largo Bus Stopbus bus
    8h 44m
    $164–640

Chicago to Key Largo by bus

Calendar8Weekly Buses
Duration32hAverage Duration
Ticket$154Cheapest Price
See schedules

Questions & Answers

What companies run services between Chicago, IL, USA and Key Largo, FL, USA?

You can take a bus from Chicago Bus Station to Key Largo Bus Stop via Atlanta Bus Station and Miami Airport Station in around 32h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Chicago

Trips to Key Largo

Popular routes