The bus between Brussels and Siena takes 20h 55m. There is at least one bus per day from Brussels to Siena. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Brussels and Siena. The earliest departure is at 4:00 PM in the afternoon, and the last departure from Brussels is at 8:00 PM which arrives into Siena at 6:55 PM. All services require a transfer, and take on average 20h 55m. The schedules shown below are for the next available departures.
Arrives next day

22h 55m • 1 change
Arrives next day

22h 55m • 1 change
Arrives next day

22h 55m • 1 change
Arrives next day

22h 55m • 1 change
Want to know about travelling from Brussels to Siena? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Brussels to Siena. However, there are services departing from Brussels station and arriving at Siena station via Milan. The journey, including transfers, takes approximately 20h 55m.
Brussels to Siena bus services, operated by FlixBus, depart from Brussels-North train station.
Brussels to Siena bus services, operated by FlixBus, arrive at Siena station.
Book your Brussels to Siena bus tickets online with FlixBus.
The distance between Brussels and Siena is 989.4 km. The road distance is 1,234 km.
You can take a bus from Brussels-North train station to Siena via Milano, Autostazione Lampugnano in around 18h 20m.