Rome2Rio

Boston to Key Largo buses

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Trip Overview

The average bus between Boston and Key Largo takes 38h 42m and the fastest bus takes 37h 10m. The bus runs, on average, 4 times per week from Boston to Key Largo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

38h 42m
Duration
1,635 mi
Distance
$317
Average price
4 times a week
Frequency

Boston to Key Largo bus times

Buses run 4 times a week between Boston and Key Largo. The earliest departure is at 3:05 PM in the afternoon, and the last departure from Boston is at 5:15 PM which arrives into Key Largo at 6:25 AM. All services require a transfer at Newark Penn Station and take an average of 38h 42m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USA37h 10m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAGreyhound USA37h 10m • 2 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Greyhound USAFlixbus USAGreyhound USA39h 20m • 2 changes

Frequently asked questions

Want to know about travelling from Boston to Key Largo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Boston to Key Largo.ExpandLaunch map view
  • Distance: 1,634.8 mi
  • Duration: 38h 42m

What companies run services between Boston, MA, USA and Key Largo, FL, USA?

You can take a bus from Boston to Key Largo Bus Stop via Newark Penn Station and Miami Airport Station in around 34h 5m.

Operators