There are 4 ways to get from Spoleto to Isernia by train (Trenitalia), bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Spoleto to Roma Tiburtinatrain 4153 / ...
- Take the train from Roma Tiburtina to Iserniatrain Re
4h 38m€21–42Bus
- Take the bus from Palombara to Roma, Autostazione Tiburtinabus E433
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
6h 35m€23–55Drive 243.2 km
- Drive from Spoleto to Iserniacar 243.2 km
3h 36m€38–55Train via Rome
- Take the train from Spoleto to Roma Terminitrain 4153 / ...
- Take the train from Roma Termini to Iserniatrain Re
4h 44m€21–67
Spoleto to Isernia by train
Questions & Answers
The cheapest way to get from Spoleto to Isernia is to train which costs €20 - €45 and takes 4h 38m.
The fastest way to get from Spoleto to Isernia is to drive which takes 3h 36m and costs €35 - €55.
No, there is no direct bus from Spoleto to Isernia. However, there are services departing from Via Nursina and arriving at Isernia via Palombara and Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 6h 35m.
No, there is no direct train from Spoleto to Isernia. However, there are services departing from Spoleto and arriving at Isernia via Roma Tiburtina. The journey, including transfers, takes approximately 4h 38m.
The distance between Spoleto and Isernia is 305 km. The road distance is 243.2 km.
The best way to get from Spoleto to Isernia without a car is to train which takes 4h 38m and costs €20 - €45.
It takes approximately 4h 38m to get from Spoleto to Isernia, including transfers.
Spoleto to Isernia bus services, operated by Busitalia - Sita Nord s.r.l., depart from Palombara station.
Spoleto to Isernia train services, operated by Trenitalia S.p.A., depart from Spoleto station.
The best way to get from Spoleto to Isernia is to train which takes 4h 38m and costs €20 - €45. Alternatively, you can bus, which costs €23 - €55 and takes 6h 35m.
What companies run services between Spoleto, Italy and Isernia, Italy?
You can take a train from Spoleto to Isernia via Roma Tiburtina in around 4h 38m. Alternatively, you can take a bus from Via Nursina to Isernia via Palombara and Roma, Autostazione Tiburtina in around 6h 35m.
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Spoleto to Roma Tiburtina
- Ave. Duration
- 1h 24m
- Frequency
- Every 2 hours
- Estimated price
- €11–25
- Website
- https://www.trenitalia.com/en.html
Train from Roma Tiburtina to Isernia
- Ave. Duration
- 2h 14m
- Frequency
- 6 times a week
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Spoleto to Roma Termini
- Ave. Duration
- 1h 36m
- Frequency
- Every 2 hours
- Estimated price
- €11–24
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Spoleto to Roma Tiburtina
- Ave. Duration
- 1h 27m
- Frequency
- 3 times a day
- Estimated price
- €9–18
- Website
- https://www.trenitalia.com/en.html
Train from Spoleto to Roma Termini
- Ave. Duration
- 1h 44m
- Frequency
- 3 times a day
- Estimated price
- €9–18
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Spoleto to Roma Termini
- Ave. Duration
- 1h 22m
- Frequency
- Once daily
- Estimated price
- €13–50
- Schedules at
- trenitalia.com
- Super Economy
- €13–18
- Base Standard
- €28–40
- Base Premium
- €35–50
- Phone
- +39 06 44101
- fsbusitalia@pec.it
- Website
- fsbusitalia.it
Bus from Palombara to Roma, Autostazione Tiburtina
- Ave. Duration
- 2h 17m
- Frequency
- Once a week
- Estimated price
- €13–17
- Website
- https://www.fsbusitalia.it/eng.html
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €11–35
- Website
- https://www.flixbus.co.uk
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More Questions & Answers
Spoleto to Isernia bus services, operated by Busitalia - Sita Nord s.r.l., arrive at Roma, Autostazione Tiburtina station.
Spoleto to Isernia train services, operated by Trenitalia S.p.A., arrive at Roma Tiburtina station.
Yes, the driving distance between Spoleto to Isernia is 243 km. It takes approximately 3h 36m to drive from Spoleto to Isernia.
There are 419+ hotels available in Isernia.























