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How to get fromSafety Harbor to Key Westby plane, bus, ferry, train, car, shuttle, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Safety Harbor to Key West by plane, bus, ferry, train, car, shuttle, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Saint Petersburg–Clearwater International Airport

    best
    1. Fly from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW)plane plane PIE - EYW
    1h 20m
    $62–278

  2. Bus, ferry

    1. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus FlixBus 2421
    2. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry Fort Myers Beach
    11h 44m
    $205–236

  3. Train, bus

    1. Take the train from Tampa to Delray Beach Amtraktrain train
    2. Take the train from Delray Beach Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    13h 30m
    $139–257

  4. Drive 400.7 mi

    1. Drive from Safety Harbor to Key Westcar car 400.7 mi
    7h 59m
    $74–106

  5. Fly from Tampa

    1. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    1h 46m
    $130–454

  6. Bus, shuttle

    1. Take the bus from University of South Florida - 3801 USF Holly Dr to Miami Airportbus bus Tallahassee
    2. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus To the Keys
    12h 8m
    $308–422

  7. Bus

    1. Take the bus from Tampa Bus Station to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    15h 13m
    $102–180

Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW) flights

Calendar6Weekly Planes
Duration1h 4mAverage Duration
Ticket$34Cheapest Price
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Questions & Answers

Map of how to get from Safety Harbor to Key West.ExpandLaunch map view
  • Distance: 248.5 mi
  • Duration: 1h 20m

What companies run services between Safety Harbor, FL, USA and Key West, FL, USA?

Allegiant Air flies from Saint Petersburg–Clearwater International Airport (PIE) to Key West International Airport (EYW) 6 times a week. Alternatively, you can take a vehicle from Safety Harbor to N Roosevelt & 3rd Street via Airport Rental Car Facility, Marion Transit Center, Tampa Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 15h 13m.

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