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There are 3 ways to get from Fort Myers to Key West by ferry, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Ferry  •  3h 55m

  1. Take the ferry from Fort Myers Beach, FL to Key West, FL Fort Myers Beach

$129 - $135

2 alternative options

Bus  •  9h 25m

  1. Take the bus from Ft Myers to Miami "Greyhound"
  2. Take the bus from Miami International Airport to Key West 2414

Drive  •  5h 44m

  1. Drive from Fort Myers to Key West 297.1 miles

$29 - $45

Fort Myers to Key West by bus

The bus journey time between Fort Myers and Key West is around 29h 30m and covers a distance of around 362 miles. The fastest bus normally takes 29h 30m. Operated by Greyhound USA and FlixBus-us, the Fort Myers to Key West bus service departs from Ft Myers and arrives in Key West. Typically three buses run weekly, although weekend and holiday schedules can vary so check in advance.

Bus route overview

Average bus time:
29h 30m
Fastest bus time:
29h 30m
Bus distance:
362 miles
Buses per week:
3
Cheapest price:
-
Carbon emissions:
72 kg CO2

First and last buses

First bus departs at:
11:00
Last bus departs at:
11:00

The schedules shown below are for the next available departures.

Fort Myers to Key West bus schedules

Fort Myers → Key West
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Travel safe during COVID-19

Rules to follow in United States

2m

Recommended

Recommended

Travel within United States

Domestic border crossings may be subject to approval, testing and quarantine

COVID-19 help in United States

If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 800-232-4636

Frequently Asked Questions


Yes, travel within United States is currently allowed.

Explore travel options

Domestic travel is not restricted, but some conditions may apply

  • Face masks are recommended
  • There is a social distancing requirement of 2 metres
  • Domestic border crossings may be subject to approval, testing and quarantine

Explore travel options

The national COVID-19 helpline number in Key West is 800-232-4636.

Wearing a face mask on public transport in Key West is recommended.

The social distance requirement in Key West is 2 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800-232-4636.

Last updated: 28 Jul 2021
Exceptions may apply, for full details: Centers for Disease control and prevention (CDC).

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The cheapest way to get from Fort Myers to Key West is to drive which costs $29 - $45 and takes 5h 44m.

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The fastest way to get from Fort Myers to Key West is to ferry. Taking this option will cost $125 - $140 and takes 3h 55m.

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No, there is no direct bus from Fort Myers to Key West. However, there are services departing from Ft Myers and arriving at Key West via Miami International Airport. The journey, including transfers, takes approximately 9h 25m.

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The distance between Fort Myers and Key West is 144 miles. The road distance is 297.1 miles.

Get driving directions

The best way to get from Fort Myers to Key West without a car is to ferry which takes 3h 55m and costs $125 - $140.

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It takes approximately 3h 55m to get from Fort Myers to Key West, including transfers.

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Fort Myers to Key West bus services, operated by Greyhound USA, depart from Ft Myers station.

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Fort Myers to Key West bus services, operated by FlixBus-us, arrive at Key West station.

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Yes, the driving distance between Fort Myers to Key West is 297 miles. It takes approximately 5h 44m to drive from Fort Myers to Key West.

Get driving directions

There are 124+ hotels available in Key West. Prices start at $100 USD per night.

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Map of how to get from Fort Myers to Key West.
Launch map view
  • Distance: 143.7 miles
  • Duration: 3h 55m

What companies run services between Fort Myers, FL, USA and Key West, FL, USA?

You can take a bus from Fort Myers to Key West via Miami International Airport in around 9h 25m.

Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Ft Myers to Miami
Ave. Duration
5h 5m
Frequency
4 times a week
Estimated price
$26 - $40
Website
greyhound.com
Economy
$26 - $40
Flexible
$45 - $70
FlixBus-us
Website
flixbus.com
Bus from Miami International Airport to Key West
Ave. Duration
3h 20m
Frequency
6 times a week
Schedules at
flixbus.com
Ferry operators
Key West Express
Phone
+1 239-463-5733
Website
keywestexpress.net
Ferry from Fort Myers Beach, FL to Key West, FL
Ave. Duration
3h 30m
Frequency
Once daily
Estimated price
$95
Book at
Key West Express

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