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How to get fromNatick to Buffaloby train, plane, bus (Greyhound, Flixbus), train (Amtrak), car or bus

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There are 6 ways to get from Natick to Buffalo by train, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, fly to Buffalo Niagara International Airport

    best
    1. Take the train from Natick Center to South Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    5h 9m
    $149–964
  2. Bus

    cheapest
    1. Take the bus from Framingham to Springfield Union Stationbus bus
    2. Take the bus from Springfield Union Station to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    12h 17m
    $59–149
  3. Train (Amtrak)

    1. Take the train from Framingham Amtrak to Buffalo Depew Stationtrain train Lake Shore Limited
    13h 35m
    $111–321
  4. Drive 438.9 mi

    1. Drive from Natick to Buffalocar car 438.9 mi
    7h 40m
    $81–116
  5. Fly to Rochester, bus

    1. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 18m
    $230–730
  6. Train, bus

    1. Take the train from Natick Center to Worcestertrain train
    2. Take the bus from Worcester, MA - Union Station to New York, NY - 1st Avenue between East 38th and 39th Streetsbus bus
    3. Take the bus from New York to Buffalobus bus
    14h 47m
    $86–368

Natick to Buffalo by train and bus

Calendar7Weekly Services
Duration12h 17mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

What companies run services between Natick, MA, USA and Buffalo, NY, USA?

You can take a train from Natick Center to Buffalo via Framingham, Framingham, Springfield Union Station, and Syracuse Bus Station in around 12h 17m. Alternatively, Amtrak operates a train from Framingham Amtrak to Buffalo Depew Station once daily. Tickets cost $100–240 and the journey takes 11h 4m.

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