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How to get fromNatick to Buffaloby train, plane, bus (Greyhound), train (Amtrak), car, bus or bus (Flixbus)

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There are 6 ways to get from Natick to Buffalo by train, plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, fly to Buffalo Niagara International Airport

    best
    1. Take the train from Natick Center to South Stationtrain train
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    4h 55m
    $140–964

  2. Bus via Ithaca

    cheapest
    1. Take the bus from Boston to Ithacabus bus FlixBus 2691
    2. Take the bus from Ithaca to Buffalobus bus FlixBus N2687 / ...
    14h 9m
    $76–194

  3. Bus (Greyhound)

    1. Take the bus from Boston to Buffalobus bus Greyhound US0171
    11h 50m
    $77–154

  4. Train (Amtrak)

    1. Take the train from Framingham Amtrak to Buffalo Depew Stationtrain train Lake Shore Limited
    13h 35m
    $130–361

  5. Drive 438.9 mi

    1. Drive from Natick to Buffalocar car 438.9 mi
    7h 40m
    $81–116

  6. Fly to Rochester, bus

    1. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 17m
    $262–832

Natick to Buffalo by bus (Greyhound)

Calendar7Weekly Buses
Duration11h 50mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

What companies run services between Natick, MA, USA and Buffalo, NY, USA?

Greyhound USA operates a bus from Boston to Buffalo once daily. Tickets cost $75–150 and the journey takes 10h 5m. Alternatively, Amtrak operates a train from Framingham Amtrak to Buffalo Depew Station once daily. Tickets cost $120–280 and the journey takes 11h 4m.

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