There are 6 ways to get from Natick to Buffalo by train, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, fly to Buffalo Niagara International Airport
best- Take the train from Natick Center to South Stationtrain
- Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane BOS - BUF
5h 9m$149–964Bus
cheapest- Take the bus from Framingham to Springfield Union Stationbus
- Take the bus from Springfield Union Station to Syracuse Bus Stationbus
- Take the bus from Syracuse Bus Station to Buffalobus
12h 17m$59–149Train (Amtrak)
- Take the train from Framingham Amtrak to Buffalo Depew Stationtrain Lake Shore Limited
13h 35m$111–321Drive 438.9 mi
- Drive from Natick to Buffalocar 438.9 mi
7h 40m$81–116Fly to Rochester, bus
- Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane BOS - ROC
- Take the bus from Rochester Bus Stop to Buffalobus
6h 18m$230–730Train, bus
- Take the train from Natick Center to Worcestertrain
- Take the bus from Worcester, MA - Union Station to New York, NY - 1st Avenue between East 38th and 39th Streetsbus
- Take the bus from New York to Buffalobus
14h 47m$86–368
Natick to Buffalo by train and bus
Questions & Answers
The cheapest way to get from Natick to Buffalo is to bus which costs $55 - $150 and takes 12h 17m.
The fastest way to get from Natick to Buffalo is to train and fly which takes 5h 9m and costs $140 - $1,000.
No, there is no direct train from Natick to Buffalo. However, there are services departing from Natick Center and arriving at Buffalo via Framingham Amtrak and Buffalo Depew Station. The journey, including transfers, takes approximately 13h 35m.
The distance between Natick and Buffalo is 431 miles. The road distance is 441.5 miles.
The best way to get from Natick to Buffalo without a car is to bus which takes 12h 17m and costs $55 - $150.
It takes approximately 5h 9m to get from Natick to Buffalo, including transfers.
Natick to Buffalo train services, operated by Amtrak, depart from Framingham Amtrak station.
The best way to get from Natick to Buffalo is to bus which takes 12h 17m and costs $55 - $150. Alternatively, you can train, which costs $110 - $330 and takes 13h 35m.
Natick to Buffalo train services, operated by Amtrak, arrive at Buffalo Depew Station.
Yes, the driving distance between Natick to Buffalo is 441 miles. It takes approximately 7h 40m to drive from Natick to Buffalo.
What companies run services between Natick, MA, USA and Buffalo, NY, USA?
You can take a train from Natick Center to Buffalo via Framingham, Framingham, Springfield Union Station, and Syracuse Bus Station in around 12h 17m. Alternatively, Amtrak operates a train from Framingham Amtrak to Buffalo Depew Station once daily. Tickets cost $100–240 and the journey takes 11h 4m.
- Website
- aa.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 47m
- When
- Monday, Tuesday, Wednesday, Thursday, and Sunday
- Estimated price
- $140–900
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Philadelphia
- Ave. Duration
- 3h 56m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $160–1,000
Flights from Boston Logan Airport to Rochester
- Ave. Duration
- 1h 39m
- When
- Every day
- Estimated price
- $75–500
Flights from Boston Logan Airport to Rochester via Philadelphia
- Ave. Duration
- 4h 4m
- When
- Sunday
- Estimated price
- $95–600
- Website
- delta.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 3h 52m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–950
Flights from Boston Logan Airport to Rochester via New York La Guardia
- Ave. Duration
- 4h 4m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $85–550
Flights from Boston Logan Airport to Rochester via New York JFK
- Ave. Duration
- 3h 58m
- When
- Every day
- Estimated price
- $85–550
- Website
- united.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Washington Dulles
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $180–1,100
Flights from Boston Logan Airport to Rochester via Newark
- Ave. Duration
- 3h 51m
- When
- Wednesday and Sunday
- Estimated price
- $85–550
Flights from Boston Logan Airport to Rochester via Washington Dulles
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $110–650
- Website
- southwest.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 3h 55m
- When
- Tuesday and Wednesday
- Estimated price
- $180–1,100
Flights from Boston Logan Airport to Rochester via Baltimore
- Ave. Duration
- 4h 2m
- When
- Tuesday, Wednesday, and Saturday
- Estimated price
- $100–600
- Website
- jetblue.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 39m
- When
- Every day
- Estimated price
- $140–900
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York JFK
- Ave. Duration
- 3h 48m
- When
- Monday to Saturday
- Estimated price
- $150–950
- Phone
- +1-617-222-3200
- Website
- mbta.com
Train from Natick Center to South Station
- Ave. Duration
- 45 min
- Frequency
- Hourly
- Estimated price
- $3–9
- Website
- https://www.mbta.com
- Adult
- $3–9
Train from Natick Center to Worcester
- Ave. Duration
- 56 min
- Frequency
- Hourly
- Estimated price
- $4–11
- Website
- https://www.mbta.com
- Adult
- $4–11
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Framingham Amtrak to Buffalo Depew Station
- Ave. Duration
- 11h 4m
- Frequency
- Once daily
- Estimated price
- $100–240
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Framingham to Springfield Union Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $12–23
- Website
- https://www.greyhound.com/
Bus from Springfield Union Station to Syracuse Bus Station
- Ave. Duration
- 4h 50m
- Frequency
- Once daily
- Estimated price
- $35–70
- Website
- https://www.greyhound.com/
Bus from Syracuse Bus Station to Buffalo
- Ave. Duration
- 3h 20m
- Frequency
- 4 times a day
- Estimated price
- $26–50
- Website
- https://www.greyhound.com/
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 25m
- Frequency
- 4 times a day
- Estimated price
- $12–22
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Springfield Union Station to Syracuse Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- 5 times a week
- Estimated price
- $27–50
- Schedules at
- flixbus.com
Bus from Syracuse Bus Station to Buffalo
- Ave. Duration
- 2h 55m
- Frequency
- Every 4 hours
- Estimated price
- $18–35
- Schedules at
- flixbus.com
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 20m
- Frequency
- Every 3 hours
- Estimated price
- $8–15
- Schedules at
- flixbus.com
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Syracuse Bus Station to Buffalo
- Ave. Duration
- 3h 10m
- Frequency
- 5 times a day
- Estimated price
- $28–95
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $28–90
- Flexible
- $55–95
Bus from New York to Buffalo
- Ave. Duration
- 8h
- Frequency
- Every 4 hours
- Estimated price
- $60–280
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Saver
- $60–260
- Flexible
- $110–280
- Phone
- +1-844-800-6828
- pr@ourbus.com
- Website
- ourbus.com
Bus from Worcester, MA - Union Station to New York, NY - 1st Avenue between East 38th and 39th Streets
- Ave. Duration
- 3h 30m
- Frequency
- 4 times a week
- Estimated price
- $20–70
- Website
- https://www.ourbus.com
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