There are 6 ways to get from Natick to Buffalo by train, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, fly to Buffalo Niagara International Airport
best- Take the train from Natick Center to South Station
- Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)BOS - BUF
4h 58m$158–1,066Bus
cheapest- Take the bus from Boston, MA to Syracuse, NYOurBus
- Take the bus from Syracuse, NY to Buffalo, NYOurBus
13h 2m$46–171Bus via Springfield
- Take the bus from Framingham to Springfield Union Station
- Take the bus from Springfield Union Station to Syracuse Bus Station
- Take the bus from Syracuse Bus Station to Buffalo
11h 48m$89–161Train (Amtrak)
- Take the train from Framingham Amtrak to Buffalo Depew StationLake Shore Limited
13h 35m$56–241Drive 438.9 mi
- Drive from Natick to Buffalo438.9 mi
7h 38m$81–116Fly to Rochester, bus
- Fly from Boston Logan Airport (BOS) to Rochester (ROC)BOS - ROC
- Take the bus from Rochester, NY to Buffalo, NY
6h 57m$218–671
Natick to Buffalo by train and bus
Questions & Answers
The cheapest way to get from Natick to Buffalo is to bus which costs $45 - $180 and takes 13h 2m.
The fastest way to get from Natick to Buffalo is to train and fly which takes 4h 58m and costs $150 - $1,100.
No, there is no direct train from Natick to Buffalo. However, there are services departing from Natick Center and arriving at Buffalo via Framingham Amtrak and Buffalo Depew Station. The journey, including transfers, takes approximately 13h 35m.
The distance between Natick and Buffalo is 430 miles. The road distance is 441.5 miles.
The best way to get from Natick to Buffalo without a car is to bus via Springfield which takes 11h 48m and costs $85 - $170.
It takes approximately 4h 58m to get from Natick to Buffalo, including transfers.
Natick to Buffalo train services, operated by Amtrak, depart from Framingham Amtrak station.
The best way to get from Natick to Buffalo is to bus via Springfield which takes 11h 48m and costs $85 - $170. Alternatively, you can train, which costs $55 - $250 and takes 13h 35m.
Natick to Buffalo train services, operated by Amtrak, arrive at Buffalo Depew Station.
Yes, the driving distance between Natick to Buffalo is 441 miles. It takes approximately 7h 38m to drive from Natick to Buffalo.
What companies run services between Natick, MA, USA and Buffalo, NY, USA?
You can take a train from Natick Center to Buffalo via Framingham, Framingham, Springfield Union Station, and Syracuse Bus Station in around 11h 48m. Alternatively, Amtrak operates a train from Framingham Amtrak to Buffalo Depew Station once daily. Tickets cost $45–160 and the journey takes 11h 4m.
- Website
- aa.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 47m
- When
- Sunday
- Estimated price
- $150–950
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Reagan Washington
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $200–1,200
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $170–1,000
Flights from Boston Logan Airport to Rochester
- Ave. Duration
- 1h 39m
- When
- Every day
- Estimated price
- $75–470
Flights from Boston Logan Airport to Rochester via Philadelphia
- Ave. Duration
- 4h 4m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $90–550
- Website
- southwest.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- $190–1,100
Flights from Boston Logan Airport to Rochester via Baltimore
- Ave. Duration
- 3h 53m
- When
- Monday
- Estimated price
- $100–600
- Website
- delta.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 3h 58m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–1,000
Flights from Boston Logan Airport to Rochester via New York La Guardia
- Ave. Duration
- 3h 57m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $80–500
Flights from Boston Logan Airport to Rochester via New York JFK
- Ave. Duration
- 4h 3m
- When
- Monday
- Estimated price
- $85–500
- Website
- jetblue.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 42m
- When
- Every day
- Estimated price
- $150–950
Flights from Boston Logan Airport to Rochester via New York JFK
- Ave. Duration
- 3h 52m
- When
- Every day
- Estimated price
- $85–500
- Website
- united.com
Flights from Boston Logan Airport to Rochester via Newark
- Ave. Duration
- 3h 57m
- When
- Monday
- Estimated price
- $80–500
- Phone
- +1-617-222-3200
- Website
- mbta.com
Train from Natick Center to South Station
- Ave. Duration
- 45 min
- Frequency
- Hourly
- Estimated price
- $3–9
- Website
- https://www.mbta.com
- Adult
- $3–9
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Framingham Amtrak to Buffalo Depew Station
- Ave. Duration
- 11h 4m
- Frequency
- Once daily
- Estimated price
- $45–160
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $45–120
- Coach Seat short notice purchase
- $60–160
- Business - advance purchase
- $80–350
- Business Class
- $130–380
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Framingham to Springfield Union Station
- Ave. Duration
- 1h 40m
- Frequency
- Twice daily
- Estimated price
- $22–35
- Website
- https://www.greyhound.com/
Bus from Springfield Union Station to Syracuse Bus Station
- Ave. Duration
- 4h 50m
- Frequency
- Twice daily
- Estimated price
- $45–75
- Website
- https://www.greyhound.com/
Bus from Syracuse Bus Station to Buffalo
- Ave. Duration
- 3h 20m
- Frequency
- Every 4 hours
- Estimated price
- $27–45
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Springfield Union Station to Syracuse Bus Station
- Ave. Duration
- 4h 35m
- Frequency
- Twice daily
- Estimated price
- $40–65
- Schedules at
- flixbus.com
Bus from Syracuse Bus Station to Buffalo
- Ave. Duration
- 2h 55m
- Frequency
- Hourly
- Estimated price
- $27–45
- Schedules at
- flixbus.com
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Syracuse Bus Station to Buffalo
- Ave. Duration
- 3h 5m
- Frequency
- 4 times a day
- Estimated price
- $25–40
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Phone
- +1-844-800-6828
- pr@ourbus.com
- Website
- ourbus.com
Bus from Rochester, NY to Buffalo, NY
- Ave. Duration
- 1h
- Frequency
- Once daily
- Estimated price
- $20–55
- Website
- https://www.ourbus.com
Bus from Boston, MA to Syracuse, NY
- Ave. Duration
- 6h 25m
- Frequency
- Twice a week
- Estimated price
- $20–90
- Website
- https://www.ourbus.com
Bus from Syracuse, NY to Buffalo, NY
- Ave. Duration
- 2h 45m
- Frequency
- 4 times a week
- Estimated price
- $20–65
- Website
- https://www.ourbus.com
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