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How to get fromMyrtle Beach to Buffaloby plane, bus (Greyhound, Flixbus), bus, train, car or bus (Greyhound)

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There are 6 ways to get from Myrtle Beach to Buffalo by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    5h 11m
    $174–992

  2. Drive 759 mi

    cheapest
    1. Drive from Myrtle Beach to Buffalocar car 759 mi
    15h 32m
    $139–201

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Newark Penn Stationbus bus
    4. Take the bus from Newark Penn Station to Buffalobus bus
    24h 30m
    $152–276

  4. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    26h 54m
    $197–373

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    5h 26m
    $164–747

  6. Bus via Chesapeake

    1. Take the bus from Myrtle Beach Bus Station to Norfolkbus bus
    2. Take the bus from Norfolk, VA - Best Square to Times Square – 37th St.bus bus
    3. Take the bus from New York to Buffalobus bus
    25h 51m
    $160–438

Myrtle Beach to Buffalo by bus

Calendar7Weekly Buses
Duration24h 30mAverage Duration
Ticket$152Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 3 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Buffalo via Wilmington Cape Fear Public Transit, Raleigh Bus Station, and Newark Penn Station in around 24h 30m.

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