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How to get fromMyrtle Beach to Buffaloby plane, bus (Greyhound, Flixbus), bus, train, car or bus (Greyhound)

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There are 7 ways to get from Myrtle Beach to Buffalo by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    4h 51m
    $195–1,140

  2. Fly to Niagara Falls International Airport, line 40 bus

    cheapest
    1. Fly from Myrtle Beach (MYR) to Niagara Falls International Airport (IAG)plane plane MYR - IAG
    2. Take the bus from Main Street & Walnut Avenue to Niagara Street & South Elmwood Avenuebus bus
    4h 40m
    $74–376

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Newark Penn Stationbus bus
    4. Take the bus from Newark Penn Station to Buffalobus bus
    24h 30m
    $155–338

  4. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    26h 54m
    $276–639

  5. Drive 759 mi

    1. Drive from Myrtle Beach to Buffalocar car 759 mi
    15h 32m
    $139–201

  6. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    4h 36m
    $156–656

  7. Bus via Chesapeake

    1. Take the bus from Myrtle Beach Bus Station to Norfolkbus bus
    2. Take the bus from Norfolk, VA - Best Square to Times Square – 37th St.bus bus
    3. Take the bus from New York to Buffalobus bus
    25h 51m
    $169–447

Myrtle Beach to Buffalo by bus

Calendar7Weekly Buses
Duration24h 30mAverage Duration
Ticket$155Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Buffalo, NY, USA?

Southwest Airlines, Delta, and American Airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Buffalo via Wilmington Cape Fear Public Transit, Raleigh Bus Station, and Newark Penn Station in around 24h 30m.

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