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How to get fromMyrtle Beach to Buffaloby plane, bus (Greyhound), bus, train, car or bus (Greyhound, Flixbus)

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There are 6 ways to get from Myrtle Beach to Buffalo by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    5h 11m
    $204–1,192

  2. Bus

    cheapest
    1. Take the bus from Myrtle Beach, SC to Charlotte Bus Stationbus bus
    2. Take the bus from Charlotte Bus Station to Charleston Bus Stationbus bus
    3. Take the bus from Charleston, WV to Akron, OHbus bus
    4. Take the bus from Akron, OH to Buffalo, NYbus bus
    23h 55m
    $137–323

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    26h 54m
    $202–665

  4. Drive 758.9 mi

    1. Drive from Myrtle Beach to Buffalocar car 758.9 mi
    15h 26m
    $139–201

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    5h 26m
    $164–517

  6. Bus via Chesapeake

    1. Take the bus from Myrtle Beach Bus Station to Norfolkbus bus
    2. Take the bus from Norfolk to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Ithacabus bus
    4. Take the bus from Ithaca to Buffalobus bus
    29h 40m
    $185–398

Myrtle Beach to Buffalo by bus

Calendar7Weekly Buses
Duration23h 55mAverage Duration
Ticket$137Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 3 hours. Alternatively, you can take a bus from Myrtle Beach, SC to Buffalo, NY via Charlotte Bus Station, Charleston, WV, and Akron, OH in around 23h 55m.

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