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How to get fromMyrtle Beach to Buffaloby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 6 ways to get from Myrtle Beach to Buffalo by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    4h 34m
    $109–593

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Newark Penn Stationbus bus
    4. Take the bus from Newark Penn Station to Buffalobus bus
    24h 33m
    $162–322

  3. Bus, train via New York

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    27h 3m
    $385–798

  4. Drive 759 mi

    1. Drive from Myrtle Beach to Buffalocar car 759 mi
    15h 33m
    $139–201

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    4h 10m
    $221–758

  6. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the train from Raleigh Union Station to Pittsburgh Amtrak Stationtrain train
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    35h
    $295–710

Myrtle Beach to Buffalo by bus

Calendar14Weekly Buses
Duration24h 33mAverage Duration
Ticket$162Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Buffalo.ExpandLaunch map view
  • Distance: 656.2 mi
  • Duration: 4h 34m

What companies run services between Myrtle Beach, SC, USA and Buffalo, NY, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Myrtle Beach Bus Station to Buffalo via Wilmington Cape Fear Public Transit, Raleigh Bus Station, and Newark Penn Station in around 24h 33m.

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