Rome2Rio

How to get fromMyrtle Beach to Buffaloby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Find Transport to Buffalo

See all options

There are 7 ways to get from Myrtle Beach to Buffalo by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF)plane plane MYR - BUF
    3h 3m
    $117–642

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the bus from Fayetteville Bus Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to Buffalobus bus
    23h 8m
    $173–282

  3. Bus, train via Fayetteville

    1. Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus bus
    2. Take the train from Fayetteville Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    24h 58m
    $568–892

  4. Drive  759.4 mi

    1. Drive from Myrtle Beach to Buffalocar car 759.4 mi
    15h 29m
    $135–194

  5. Fly to Rochester, bus

    1. Fly from Myrtle Beach (MYR) to Rochester (ROC)plane plane MYR - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    4h 20m
    $171–807

  6. Bus via Raleigh

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Buffalobus bus
    25h 1m
    $190–460

  7. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    27h 8m
    $658–1,057

Myrtle Beach to Buffalo by bus

Calendar8Weekly Buses
Duration23h 8mAverage Duration
Ticket$173Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Myrtle Beach to Buffalo.ExpandLaunch map view
  • Distance: 651.8 mi
  • Duration: 3h 3m

What companies run services between Myrtle Beach, SC, USA and Buffalo, NY, USA?

Breeze Airways, Southwest Airlines, and two other airlines fly from Myrtle Beach (MYR) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Buffalo via Fayetteville Bus Station and Newark Penn Station in around 23h 8m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There