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How to get fromMobile to Des Moinesby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)

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There are 8 ways to get from Mobile to Des Moines by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mobile Regional Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Des Moines (DSM)plane plane MOB - DSM
    8h 2m
    $181–802

  2. Drive  957.6 mi

    cheapest
    1. Drive from Mobile to Des Moinescar car 957.6 mi
    18h 6m
    $175–253

  3. Bus

    1. Take the bus from Mobile Bus Station to Baton Rouge Bus Stationbus bus
    2. Take the bus from Baton Rouge Bus Station to Shreveport Bus Stationbus bus
    3. Take the bus from Shreveport Bus Station to Texarkanabus bus
    4. Take the bus from Texarkana to Kansas Citybus bus
    5. Take the bus from Kansas City to Des Moinesbus bus
    27h 22m
    $235–389

  4. Train, bus

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain train
    3. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus
    30h 8m
    $290–649

  5. Train to Gulfport-Biloxi Regional Airport, fly

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Des Moines (DSM)plane plane GPT - DSM
    7h 28m
    $241–1,031

  6. Bus to Destin–Fort Walton Beach Airport, fly

    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane plane VPS - DSM
    7h 50m
    $266–947

  7. Bus to Pensacola International Airport, fly

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Des Moines (DSM)plane plane PNS - DSM
    8h 14m
    $176–788

  8. Bus via Indianapolis (Greyhound)

    1. Take the bus from Mobile Bus Station to Montgomery Intermodal Centerbus bus
    2. Take the bus from Montgomery Intermodal Center to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    30h 2m
    $186–369

Mobile to Des Moines by bus

Calendar6Weekly Buses
Duration27h 22mAverage Duration
Ticket$235Cheapest Price
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Questions & Answers

Map of how to get from Mobile to Des Moines.ExpandLaunch map view
  • Distance: 836.7 mi
  • Duration: 8h 2m

What companies run services between Mobile, AL, USA and Des Moines, IA, USA?

Delta, United Airlines, and American Airlines fly from Mobile Regional Airport (MOB) to Des Moines (DSM) every 3 hours. Alternatively, you can take a bus from St Joseph SB Near St Louis St to Des Moines via Govt WB Across from Greyhound, Mobile Bus Station, Baton Rouge Bus Station, Shreveport Bus Station, Texarkana, and Kansas City in around 27h 22m.

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