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How to get fromMobile to Des Moinesby bus, plane, bus (Greyhound, Flixbus), train, car or bus (Flixbus)

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There are 8 ways to get from Mobile to Des Moines by bus, plane, bus (Greyhound, Flixbus), train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly

    best
    1. Take the bus from Mobile to Crestviewbus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)planeVPS - DSM
    5h 46m
    $256–947
  2. Bus via New South Memphis

    cheapest
    1. Take the bus from Mobile Bus Station to Lafayettebus
    2. Take the bus from Lafayette to Memphis Bus Stationbus
    3. Take the bus from Memphis Bus Station to Kansas Citybus
    4. Take the bus from Kansas City to Des Moinesbus
    32h 17m
    $157–460
  3. Bus

    1. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus
    2. Take the bus from New Orleans Bus Station to St Louis Bus Stationbus
    3. Take the bus from St Louis to Burlingtonbus
    4. Take the bus from Burlington to Des Moinesbus
    29h 37m
    $178–375
  4. Bus, train

    1. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus
    2. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain
    3. Take the bus from Champaign to Des Moinesbus
    31h 52m
    $198–415
  5. Drive 957.6 mi

    1. Drive from Mobile to Des Moinescar957.6 mi
    18h 10m
    $175–253
  6. Fly from Mobile Regional Airport

    1. Fly from Mobile Regional Airport (MOB) to Des Moines (DSM)planeMOB - DSM
    8h 19m
    $184–840
  7. Bus to Pensacola International Airport, fly

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus
    2. Fly from Pensacola International Airport (PNS) to Des Moines (DSM)planePNS - DSM
    8h 31m
    $213–974
  8. Bus to Gulfport-Biloxi Regional Airport, fly

    1. Take the bus from Mobile to Gulfportbus
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Des Moines (DSM)planeGPT - DSM
    9h
    $306–1,099

Mobile to Des Moines by bus

Calendar7Weekly Buses
Duration29h 37mAverage Duration
Ticket$178Cheapest Price
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Questions & Answers

What companies run services between Mobile, AL, USA and Des Moines, IA, USA?

You can take a bus from St Joseph SB Near St Louis St to Des Moines via Govt WB Across from Greyhound, Mobile Bus Station, New Orleans Bus Station, St Louis, and Burlington in around 29h 37m. Alternatively, Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Des Moines (DSM) every 3 hours.

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