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How to get fromMobile to Des Moinesby bus, plane, bus (Greyhound, Flixbus), train, car or bus (Flixbus)

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There are 8 ways to get from Mobile to Des Moines by bus, plane, bus (Greyhound, Flixbus), train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly

    best
    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane plane VPS - DSM
    5h 46m
    $266–947
  2. Bus via New South Memphis

    cheapest
    1. Take the bus from Mobile Bus Station to Lafayettebus bus
    2. Take the bus from Lafayette to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Kansas Citybus bus
    4. Take the bus from Kansas City to Des Moinesbus bus
    32h 17m
    $157–460
  3. Bus

    1. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus bus
    2. Take the bus from New Orleans Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis to Burlingtonbus bus
    4. Take the bus from Burlington to Des Moinesbus bus
    29h 37m
    $178–375
  4. Bus, train

    1. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain train
    3. Take the bus from Champaign to Des Moinesbus bus
    31h 52m
    $198–415
  5. Drive 957.6 mi

    1. Drive from Mobile to Des Moinescar car 957.6 mi
    18h 10m
    $175–253
  6. Fly from Mobile Regional Airport

    1. Fly from Mobile Regional Airport (MOB) to Des Moines (DSM)plane plane MOB - DSM
    8h 29m
    $195–876
  7. Bus to Pensacola International Airport, fly

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Des Moines (DSM)plane plane PNS - DSM
    8h 28m
    $233–1,074
  8. Bus to Gulfport-Biloxi Regional Airport, fly

    1. Take the bus from Mobile to Gulfportbus bus
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Des Moines (DSM)plane plane GPT - DSM
    9h 11m
    $316–1,149

Mobile to Des Moines by bus

Calendar7Weekly Buses
Duration29h 37mAverage Duration
Ticket$178Cheapest Price
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Questions & Answers

What companies run services between Mobile, AL, USA and Des Moines, IA, USA?

You can take a bus from St Joseph SB Near St Louis St to Des Moines via Govt WB Across from Greyhound, Mobile Bus Station, New Orleans Bus Station, St Louis, and Burlington in around 29h 37m. Alternatively, Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Des Moines (DSM) every 3 hours.

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