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How to get fromMobile to Des Moinesby bus, plane, bus (Greyhound, Flixbus), train, car or bus (Flixbus)

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There are 8 ways to get from Mobile to Des Moines by bus, plane, bus (Greyhound, Flixbus), train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Destin–Fort Walton Beach Airport, fly

    best
    1. Take the bus from Mobile to Crestviewbus bus
    2. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane plane VPS - DSM
    5h 46m
    $266–947
  2. Bus

    cheapest
    1. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus bus
    2. Take the bus from New Orleans Bus Station to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Kansas Citybus bus
    4. Take the bus from Kansas City to Des Moinesbus bus
    28h 2m
    $126–378
  3. Bus, train

    1. Take the bus from Mobile Bus Station to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    32h 30m
    $198–488
  4. Drive 957.6 mi

    1. Drive from Mobile to Des Moinescar car 957.6 mi
    18h 15m
    $175–253
  5. Fly from Mobile Regional Airport

    1. Fly from Mobile Regional Airport (MOB) to Des Moines (DSM)plane plane MOB - DSM
    8h 29m
    $195–876
  6. Bus to Pensacola International Airport, fly

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Des Moines (DSM)plane plane PNS - DSM
    8h 28m
    $213–974
  7. Bus to Gulfport-Biloxi Regional Airport, fly

    1. Take the bus from Mobile to Gulfportbus bus
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Des Moines (DSM)plane plane GPT - DSM
    8h 42m
    $316–1,149
  8. Bus via Lafayette

    1. Take the bus from Mobile Bus Station to Lafayettebus bus
    2. Take the bus from Lafayette to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Kansas Citybus bus
    4. Take the bus from Kansas City to Des Moinesbus bus
    32h 17m
    $157–460

Mobile to Des Moines by bus

Calendar4Weekly Buses
Duration28h 2mAverage Duration
Ticket$126Cheapest Price
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Questions & Answers

What companies run services between Mobile, AL, USA and Des Moines, IA, USA?

You can take a bus from St Joseph SB Near St Louis St to Des Moines via Govt WB Across from Greyhound, Mobile Bus Station, New Orleans Bus Station, Memphis Bus Station, and Kansas City in around 28h 2m. Alternatively, Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Des Moines (DSM) every 3 hours.

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