There are 6 ways to get from Missouri to Tupelo by bus (Greyhound, Flixbus), car, plane, bus, train, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via St. Louis
best- Take the bus from Kansas City Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
13h 19m$104–174Drive 545.6 mi
cheapest- Drive from Kansas City to Tupelocar 545.6 mi
9h 54m$100–144Fly to Jonesboro Municipal Airport, bus
- Fly from Lambert–St. Louis International Airport (STL) to Jonesboro Municipal Airport (JBR)plane STL - JBR
- Take the bus from Jonesboro to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
8h 31m$168–522Train, bus
- Take the train from Kansas City to St. Louistrain
- Take the bus from St Louis Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
16h 5m$138–272Bus
- Take the bus from Kansas City to Tulsabus
- Take the bus from Tulsa to Memphisbus
- Take the bus from Memphis Bus Station to Tupelobus
17h 19m$191–278Fly to Nashville, bus
- Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane STL - BNA
- Take the bus from Nashville Bus Station to Memphis Bus Stationbus
- Take the bus from Memphis Bus Station to Tupelobus
10h 29m$190–848
Lambert–St. Louis International Airport (STL) to Jonesboro Municipal Airport (JBR) flights
Comparing Your Travel Options
The cheapest way to get from Missouri to Tupelo is to drive which costs $95 - $150 and takes 9h 54m.
The fastest way to get from Missouri to Tupelo is to fly and bus which takes 8h 31m and costs $160 - $550.
No, there is no direct bus from Missouri station to Tupelo. However, there are services departing from Kansas City Bus Station and arriving at Tupelo via St Louis Bus Station and Memphis Bus Station. The journey, including transfers, takes approximately 13h 19m.
The distance between Missouri and Tupelo is 646 miles. The road distance is 548.8 miles.
The best way to get from Missouri to Tupelo without a car is to bus via St. Louis which takes 13h 19m and costs $100 - $180.
It takes approximately 13h 19m to get from Missouri to Tupelo, including transfers.
Missouri to Tupelo bus services, operated by Greyhound USA, depart from Kansas City Bus Station.
Missouri to Tupelo bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Yes, the driving distance between Missouri to Tupelo is 549 miles. It takes approximately 9h 54m to drive from Missouri to Tupelo.
There are 34+ hotels available in Tupelo.
What companies run services between Missouri, USA and Tupelo, MS, USA?
You can take a bus from Kansas City Bus Station to Tupelo via St Louis Bus Station, Memphis Bus Station, and Tupelo in around 13h 19m.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Nashville
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- $60–410
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Kansas City to St. Louis
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $70–160
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Kansas City Bus Station to St Louis Bus Station
- Ave. Duration
- 4h
- Frequency
- 4 times a day
- Estimated price
- $35–65
- Website
- Greyhound
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $45–75
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Bus from Jonesboro to Memphis Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- Once daily
- Estimated price
- $11–19
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Bus from St Louis Bus Station to Memphis Bus Station
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $45–75
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Bus from Nashville Bus Station to Memphis Bus Station
- Ave. Duration
- 3h 20m
- Frequency
- 4 times a day
- Estimated price
- $30–55
- Website
- Greyhound
Bus from Memphis Bus Station to Tupelo
- Ave. Duration
- 1h 45m
- Frequency
- Twice daily
- Estimated price
- $15–25
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide






