There are 7 ways to get from Milwaukee to St. Louis by plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from General Mitchell International Airport
best- Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)MKE - STL
3h 31m$255–533Bus
cheapest- Take the bus from Milwaukee Intermodal Station to Chicago Bus StationGreyhound US0150S / ...
- Take the bus from Chicago Bus Station to St Louis Bus StationFlixBus N2521 / ...
8h 55m$55–136Train (Amtrak)
- Take the train from Milwaukee to Chicago Union StationHiawatha Service / ...
- Take the train from Chicago Union Station to St. LouisLincoln Service / ...
7h 15m$62–258Drive 371.2 mi
- Drive from Milwaukee to St. Louis371.2 mi
6h 13m$68–98Bus to Chicago O'Hare International Airport, fly
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departures
- Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)ORD - STL
4h 52m$218–531Train to Chicago Midway International Airport, fly
- Take the train from Milwaukee to Chicago Union Station
- Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)MDW - STL
5h 22m$107–596Bus, train
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 DeparturesWisconsin Coach Lines
- Take the train from Chicago Union Station to St. LouisLincoln Service / ...
8h 32m$77–263
Milwaukee to St. Louis by train (Amtrak)
Questions & Answers
The cheapest way to get from Milwaukee to St. Louis is to drive which costs $65 - $100 and takes 6h 13m.
The fastest way to get from Milwaukee to St. Louis is to fly which takes 3h 31m and costs $250 - $550.
No, there is no direct bus from Milwaukee station to St. Louis station. However, there are services departing from Milwaukee Intermodal Station and arriving at St Louis Bus Station via Chicago Bus Station. The journey, including transfers, takes approximately 8h 55m.
No, there is no direct train from Milwaukee to St. Louis. However, there are services departing from Milwaukee and arriving at St. Louis via Chicago Union Station. The journey, including transfers, takes approximately 7h 15m.
The distance between Milwaukee and St. Louis is 341 miles. The road distance is 373.4 miles.
The best way to get from Milwaukee to St. Louis without a car is to train which takes 7h 15m and costs $60 - $260.
It takes approximately 3h 31m to get from Milwaukee to St. Louis, including transfers.
Milwaukee to St. Louis bus services, operated by Greyhound USA, depart from Milwaukee Intermodal Station.
Milwaukee to St. Louis train services, operated by Amtrak, depart from Milwaukee station.
The best way to get from Milwaukee to St. Louis is to fly which takes 3h 31m and costs $250 - $550. Alternatively, you can train, which costs $60 - $260 and takes 7h 15m, you could also bus, which costs $55 - $140 and takes 8h 55m.
What companies run services between Milwaukee, WI, USA and St. Louis, MO, USA?
Southwest Airlines and American Airlines fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL) 3 times a day. Alternatively, you can take a train from Milwaukee to St. Louis via Chicago Union Station in around 7h 15m.
- Website
- southwest.com
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- $120–800
Flights from Chicago Midway International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $80–550
- Website
- aa.com
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 3h 33m
- When
- Thursday and Friday
- Estimated price
- $120–800
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $60–420
- Website
- united.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $60–420
- Website
- gojetairlines.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $60–420
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $22–40
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $40–220
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $19–65
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 2h 15m
- Frequency
- 3 times a day
- Estimated price
- $20–35
- Schedules at
- flixbus.com
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 6h 10m
- Frequency
- 3 times a day
- Estimated price
- $35–75
- Schedules at
- flixbus.com
- Phone
- (866) 912 6224
- questions@coachusa.com
- Website
- coachusa.com
Bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departures
- Ave. Duration
- 1h 50m
- Frequency
- Every 2 hours
- Estimated price
- $35–38
- Schedules at
- coachusa.com
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More Questions & Answers
Milwaukee to St. Louis bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Milwaukee to St. Louis train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Milwaukee to St. Louis is 373 miles. It takes approximately 6h 13m to drive from Milwaukee to St. Louis.
Book your Milwaukee to St. Louis train tickets online with Omio.
Book your Milwaukee to St. Louis bus tickets online with Omio and FlixBus.
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