Rome2Rio

How to get fromMilwaukee to St. Louisby plane, train (Amtrak), bus (Flixbus, Greyhound), car, bus or train

Find Transport to St. Louis

See all options

There are 7 ways to get from Milwaukee to St. Louis by plane, train (Amtrak), bus (Flixbus, Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Mitchell International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    3h 31m
    $125–883

  2. Bus

    cheapest
    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus FlixBus 2548 / ...
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus N2521 / ...
    9h 25m
    $55–127

  3. Train (Amtrak)

    1. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    7h 15m
    $62–258

  4. Drive 371.2 mi

    1. Drive from Milwaukee to St. Louiscar car 371.2 mi
    6h 16m
    $68–98

  5. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    4h 56m
    $238–531

  6. Train to Chicago Midway International Airport, fly

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    5h 22m
    $107–596

  7. Bus, train

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Take the bus from Multi-Modal Facility to Uptown Stationbus bus
    3. Take the train from Bloomington-Normal to St. Louistrain train
    10h 38m
    $100–166

Milwaukee to St. Louis by train (Amtrak)

Calendar38Weekly Trains
Duration7h 15mAverage Duration
Ticket$62Cheapest Price
See schedules

Questions & Answers

What companies run services between Milwaukee, WI, USA and St. Louis, MO, USA?

Southwest Airlines and American Airlines fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL) 3 times a day. Alternatively, you can take a train from Milwaukee to St. Louis via Chicago Union Station in around 7h 15m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Milwaukee

Trips to St. Louis

Popular routes