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There are 7 ways to get from Milwaukee to St. Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Milwaukee  •  3h 30m

  1. Fly from Milwaukee (MKE) to St. Louis (STL) MKE - STL

$135 - $275

Cheapest option

Bus Megabus  •  8h 40m

  1. Take the bus from Milwaukee, WI to Chicago
  2. Take the bus from Chicago, IL to St. Louis via St Louis

$40 - $60

5 alternative options

Bus to Chicago O'Hare, fly  •  4h 40m

  1. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
  2. Fly from Chicago O'Hare (ORD) to St. Louis (STL) ORD - STL

$109 - $276

Train to Chicago Midway, fly  •  5h 11m

  1. Take the train from Milwaukee Intermodal Station to Chicago Union Station
  2. Fly from Chicago Midway (MDW) to St. Louis (STL) MDW - STL

$153 - $366

Train  •  7h 59m

  1. Take the train from Milwaukee Intermodal Station to Chicago Union Station Hiawatha Service
  2. Take the train from Chicago Union Station to St. Louis Gateway Station Lincoln Service / ...

$78 - $189

Bus Greyhound USA  •  8h 40m

  1. Take the bus from Milwaukee, Wi to Chicago, Il 4909 / ...
  2. Take the bus from Chicago, Il to St Louis, Mo 1353 / ...

$50 - $119

Drive  •  6h 10m

  1. Drive from Milwaukee to St. Louis 373.5 miles

$35 - $55

Questions & Answers

The cheapest way to get from Milwaukee to St. Louis is to drive which costs $35 - $55 and takes 6h 10m.

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The quickest way to get from Milwaukee to St. Louis is to fly which costs $130 - $280 and takes 3h 30m.

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No, there is no direct bus from Milwaukee to St. Louis. However, there are services departing from Milwaukee, Wi and arriving at St Louis, Mo via Chicago, Il. The journey, including transfers, takes approximately 8h 40m.

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No, there is no direct train from Milwaukee station to St. Louis station. However, there are services departing from Milwaukee Intermodal Station and arriving at St. Louis Gateway Station via Chicago Union Station. The journey, including transfers, takes approximately 7h 59m.

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The distance between Milwaukee and St. Louis is 329 miles. The road distance is 373.5 miles.

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The best way to get from Milwaukee to St. Louis without a car is to train which takes 7h 59m and costs $75 - $190.

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It takes approximately 3h 30m to get from Milwaukee to St. Louis, including transfers.

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Milwaukee to St. Louis bus services, operated by Greyhound USA, depart from Milwaukee, Wi station.

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Milwaukee to St. Louis train services, operated by Amtrak, arrive at Milwaukee Intermodal Station.

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The best way to get from Milwaukee to St. Louis is to fly which takes 3h 30m and costs $130 - $280. Alternatively, you can train, which costs $75 - $190 and takes 7h 59m, you could also bus, which costs $50 - $120 and takes 8h 40m.

Mode details

Map of how to get from Milwaukee to St. Louis.
Launch map view
  • Distance: 329.4 miles
  • Duration: 3h 30m

What companies run services between Milwaukee, WI, USA and St. Louis, MO, USA?

Southwest Airlines, United Airlines and American Airlines fly from Milwaukee to St. Louis every 4 hours. Alternatively, you can take a train from Milwaukee to St. Louis via Chicago Union Station in around 7h 59m.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Milwaukee to St. Louis
Ave. Duration
1h 23m
When
Every day
Estimated price
$310 - $600
Flights from Chicago Midway to St. Louis
Ave. Duration
1h 11m
When
Every day
Estimated price
$160 - $550
United Airlines
Website
united.com
Flights from Milwaukee to St. Louis via Chicago O'Hare
Ave. Duration
3h 20m
When
Every day
Estimated price
$240 - $750
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1h 23m
When
Every day
Estimated price
$120 - $650
American Airlines
Website
aa.com
Flights from Milwaukee to St. Louis via Chicago O'Hare
Ave. Duration
3h 25m
When
Every day
Estimated price
$230 - $550
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1h 15m
When
Every day
Estimated price
$120 - $550
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Milwaukee Intermodal Station to Chicago Union Station
Ave. Duration
1h 29m
Frequency
Every 4 hours
Estimated price
$28 - $60
Website
amtrak.com
Coach Seat
$28 - $45
Flexi Coach Seat
$50 - $75
Business Coach Seat
$40 - $60
Room
$150 - $220
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5h 30m
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Coach USA
Phone
201-225-7500
Website
coachusa.com
Bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
Ave. Duration
1h 50m
Frequency
Hourly
Estimated price
$21 - $35
Schedules at
web.coachusa.com
Book at
coachusaairportexpress.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Milwaukee, Wi to Chicago, Il
Ave. Duration
1h 55m
Frequency
Every 4 hours
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$27 - $35
Bus from Chicago, Il to St Louis, Mo
Ave. Duration
5h 45m
Frequency
Every 4 hours
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Milwaukee, WI to Chicago
Ave. Duration
1h 40m
Frequency
4 times a day
Estimated price
$10 - $21
Book at
megabus.com
Bus from Chicago, IL to St. Louis
Ave. Duration
6h
Frequency
Twice daily
Estimated price
$29 - $40
Book at
megabus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from Milwaukee Airport to St. Louis Airport is the direct flight which takes 1h 20m.

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Milwaukee to St. Louis bus services, operated by Greyhound USA, arrive at St Louis, Mo station.

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Milwaukee to St. Louis train services, operated by Amtrak, arrive at St. Louis Gateway Station.

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Yes, the driving distance between Milwaukee to St. Louis is 373 miles. It takes approximately 6h 10m to drive from Milwaukee to St. Louis.

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American Airlines, Southwest Airlines and United Airlines offer flights from Milwaukee Airport to St. Louis Airport.

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Book your Milwaukee to St. Louis train tickets online with Rome2rio.

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Book your Milwaukee to St. Louis bus tickets online with Greyhound and Greyhound.

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There are 202+ hotels available in St. Louis. Prices start at $64 USD per night.

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The best way to get from Milwaukee to Milwaukee Airport is to bus which takes 29m and costs $3.

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