There are 8 ways to get from Mainz to Santander by plane, bus, train, car, train (TGV, Renfe), or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Frankfurt to Bilbao Airport, bus
best- Fly from Frankfurt (FRA) to Bilbao Airport (BIO)FRA - BIO
- Take the bus from Bilbao Intermodal to Santander E.A.
7h 40m€111–260Bus
cheapest- Take the bus from Mainz central train station to Paris, Quai de Bercy (Bercy Seine)N90 / ...
- Take the bus from Paris to SantanderFlixBus 783 / ...
21h 15m€68–157Train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, HauptbahnhofS6
- Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhof82 / ...
- Take the train from Strasbourg to Bordeaux St JeanTgv
- Take the bus from Bordeaux to Santander
17h 40m€180–390Drive 1,483 km
- Drive from Mainz to Santander1,483 km
14h 48m€234–338Fly Frankfurt to Santander Airport
- Fly from Frankfurt (FRA) to Santander Airport (SDR)FRA - SDR
8h 4m€151–276Train to Düsseldorf International Airport, fly to Bilbao Airport, bus
- Take the train from Frankfurt to Düsseldorf Hbf
- Fly from Düsseldorf International Airport (DUS) to Bilbao Airport (BIO)DUS - BIO
- Take the bus from Bilbao Intermodal to Santander E.A.
9h 41m€125–349Train
- Take the train from Frankfurt to Strasbourg Bahnhof82
- Take the train from Strasbourg to Montpellier Saint-RochTgv
- Take the train from Montpellier Saint-Roch to Madrid-Puerta de Atocha-Almudena Grandes
- Take the train from Madrid Chamartín to SantanderAlv / ...
23h 26m€241–601Night train, bus
- Take the night train from Mainz Hbf to Brussel-Zuid / Bruxelles-MidiNj
- Take the bus from Brussels - Midi Train Station to Bilbao Intermodal
- Take the bus from Bilbao Intermodal to Santander E.A.
26h 8m€81–407
Mainz to Santander by train, foot, and bus
Questions & Answers
The cheapest way to get from Mainz to Santander is to bus which costs €65 - €160 and takes 21h 15m.
The fastest way to get from Mainz to Santander is to fly and bus which takes 7h 40m and costs €110 - €260.
No, there is no direct bus from Mainz station to Santander. However, there are services departing from Mainz central train station and arriving at Santander via Paris. The journey, including transfers, takes approximately 21h 15m.
No, there is no direct train from Mainz to Santander. However, there are services departing from Mainz, Römisches Theater and arriving at Santander via Frankfurt, Strasbourg, Montpellier Saint-Roch, Madrid-Atocha Cercanías and Madrid Chamartín. The journey, including transfers, takes approximately 23h 26m.
The distance between Mainz and Santander is 1293 km. The road distance is 1483 km.
The best way to get from Mainz to Santander without a car is to train and bus which takes 17h 40m and costs €180 - €390.
It takes approximately 7h 40m to get from Mainz to Santander, including transfers.
Mainz to Santander bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Santander train services, operated by Deutsche Bahn Intercity (DB IC), depart from Frankfurt station.
The best way to get from Mainz to Santander is to bus which takes 21h 15m and costs €65 - €160. Alternatively, you can fly, which costs €150 - €280 and takes 8h 4m, you could also train, which costs €240 - €600 and takes 23h 26m.
What companies run services between Mainz, Germany and Santander, Spain?
You can take a bus from Mainz central train station to Santander via Paris, Quai de Bercy (Bercy Seine) and Paris in around 21h 15m. Alternatively, Iberia, Lufthansa, and five other airlines fly from Frankfurt (FRA) to Santander Airport (SDR) 4 times a day.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- lufthansa.com
Flights from Frankfurt to Bilbao Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- €100–240
Flights from Düsseldorf International Airport to Bilbao Airport via Frankfurt
- Ave. Duration
- 4h 5m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €90–350
Flights from Düsseldorf International Airport to Bilbao Airport via Munich
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- €90–370
- Website
- airfrance.com
Flights from Frankfurt to Bilbao Airport via Paris Charles de Gaulle
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- €55–300
Flights from Düsseldorf International Airport to Bilbao Airport via Paris Charles de Gaulle
- Ave. Duration
- 4h 25m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €55–320
- Website
- iberia.com
Flights from Frankfurt to Santander Airport via Madrid
- Ave. Duration
- 6h 28m
- When
- Every day
- Estimated price
- €85–470
Flights from Frankfurt to Santander Airport via Barcelona
- Ave. Duration
- 5h 45m
- When
- Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €120–470
- Website
- vueling.com
Flights from Frankfurt to Santander Airport via Barcelona
- Ave. Duration
- 5h 45m
- When
- Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €120–470
Flights from Frankfurt to Santander Airport via Madrid
- Ave. Duration
- 7h 12m
- When
- Every day
- Estimated price
- €85–470
- Website
- klm.com
Flights from Düsseldorf International Airport to Bilbao Airport via Amsterdam Schiphol
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- €60–330
- Website
- ryanair.com
Flights from Frankfurt to Santander Airport via Manchester
- Ave. Duration
- 5h 20m
- When
- Sunday
- Estimated price
- €100–310
- Website
- ryanair.com
Flights from Frankfurt to Santander Airport via Birmingham
- Ave. Duration
- 5h 35m
- When
- Monday
- Estimated price
- €90–300
- Website
- eurowings.com
Flights from Düsseldorf International Airport to Bilbao Airport
- Ave. Duration
- 2h 5m
- When
- Monday, Friday, and Sunday
- Estimated price
- €75–200
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Twice daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Strasbourg Bahnhof
- Ave. Duration
- 1h 10m
- Frequency
- 3 times a day
- Estimated price
- €35–65
- Website
- https://int.bahn.de/en
Train from Frankfurt to Düsseldorf Hbf
- Ave. Duration
- 1h 13m
- Frequency
- Hourly
- Estimated price
- €30–90
- Website
- https://int.bahn.de/en
Train from Frankfurt to Strasbourg Bahnhof
- Ave. Duration
- 1h 51m
- Frequency
- Once a week
- Estimated price
- €40–80
- Website
- https://int.bahn.de/en
- Phone
- +33 1 84 94 36 35
- Website
- sncf-connect.com
Train from Strasbourg to Bordeaux St Jean
- Ave. Duration
- 6h 1m
- Frequency
- Once daily
- Estimated price
- €110–250
- Website
- https://www.sncf-connect.com/en-en
Train from Strasbourg to Montpellier Saint-Roch
- Ave. Duration
- 6h 3m
- Frequency
- Once daily
- Estimated price
- €70–240
- Website
- https://www.sncf-connect.com/en-en
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Frankfurt to Düsseldorf Hbf
- Ave. Duration
- 1h 24m
- Frequency
- Every 3 hours
- Estimated price
- €30–110
- Website
- https://www.ns.nl/en
- 2nd Class
- €30–50
- 1st Class
- €65–110
- Phone
- +352 24 89 24 89
- Website
- cfl.lu
Train from Strasbourg to Montpellier Saint-Roch
- Ave. Duration
- 6h 3m
- Frequency
- Once daily
- Estimated price
- €200–300
- Website
- https://www.cfl.lu/en-gb
- 1st Class
- €200–300
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Montpellier Saint-Roch to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 6h 18m
- Frequency
- Twice daily
- Estimated price
- €75–110
- Website
- https://www.renfe.com/es/en
Train from Madrid Chamartín to Santander
- Ave. Duration
- 4h 20m
- Frequency
- Twice daily
- Estimated price
- €45–95
- Website
- https://www.renfe.com/es/en
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Mainz Hbf to Brussel-Zuid / Bruxelles-Midi
- Ave. Duration
- 5h 2m
- Frequency
- 5 times a week
- Estimated price
- €40–261
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €259–261
- Couchette Carriage
- €130–160
- Seating Carriage
- €40–55
- Phone
- +34 910 207 007
- alsa@alsa.es
- Website
- alsa.com
Bus from Bilbao Intermodal to Santander E.A.
- Ave. Duration
- 1h 40m
- Frequency
- Hourly
- Estimated price
- €8–16
- Website
- https://www.alsa.com/en/
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Bordeaux to Santander
- Ave. Duration
- 6h 5m
- Frequency
- Once daily
- Estimated price
- €21–55
- Website
- https://www.flixbus.co.uk
Bus from Mainz central train station to Paris, Quai de Bercy (Bercy Seine)
- Ave. Duration
- 7h 25m
- Frequency
- 3 times a day
- Estimated price
- €28–65
- Website
- https://www.flixbus.co.uk
Bus from Paris to Santander
- Ave. Duration
- 12h 50m
- Frequency
- Once daily
- Estimated price
- €40–95
- Website
- https://www.flixbus.co.uk
- Phone
- +3-389-268-0068
- Website
- blablacar.co.uk
Bus from Brussels - Midi Train Station to Bilbao Intermodal
- Ave. Duration
- 17h 45m
- Frequency
- 3 times a week
- Estimated price
- €30–130
- Website
- https://www.blablacar.co.uk/bus
Want to know more about travelling around Spain
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More Questions & Answers
Mainz to Santander bus services, operated by FlixBus, arrive at Paris, Quai de Bercy (Bercy Seine) station.
Mainz to Santander train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Strasbourg Bahnhof station.
Yes, the driving distance between Mainz to Santander is 1483 km. It takes approximately 14h 48m to drive from Mainz to Santander.
Book your Mainz to Santander bus tickets online with Omio and FlixBus.
There are 1993+ hotels available in Santander.




















































