There are 10 ways to get from Mainz to Santander by plane, train, bus, car, train (TGV, Renfe), or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Frankfurt to Santander Airport
best- Fly from Frankfurt (FRA) to Santander Airport (SDR)FRA - SDR
7h 24m€147–282Bus
cheapest- Take the bus from Mainz central train station to Paris, Quai de Bercy (Bercy Seine)N90 / ...
- Take the bus from Paris to SantanderFlixBus 783 / ...
21h 15m€69–192Train, bus
- Take the train from Mainz, Römisches Theater to Mannheim, HauptbahnhofS5 / ...
- Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhof82 / ...
- Take the train from Strasbourg to Bordeaux St JeanTgv
- Take the bus from Bordeaux to Santander
17h 37m€181–405Drive 1,483 km
- Drive from Mainz to Santander1,483 km
14h 48m€231–334Fly Frankfurt to Bilbao Airport, bus
- Fly from Frankfurt (FRA) to Bilbao Airport (BIO)FRA - BIO
- Take the bus from Bilbao Intermodal to Santander E.A.
7h 40m€111–270Bus to Hahn, fly to Santander Airport
- Take the bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airport
- Fly from Hahn (HHN) to Santander Airport (SDR)HHN - SDR
8h 50m€97–310Fly Frankfurt to Biarritz Pays Basque Airport, bus
- Fly from Frankfurt (FRA) to Biarritz Pays Basque Airport (BIQ)FRA - BIQ
- Take the bus from Biarritz - Airport Bus Station to Bilbao Intermodal
- Take the bus from Bilbao Intermodal to Santander E.A.
10h 5mTrain, bus via Saint-Jean-de-Luz
- Take the train from Mainz, Römisches Theater to Mannheim, HauptbahnhofS5 / ...
- Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhof82 / ...
- Take the train from Strasbourg to Bordeaux St JeanTgv
- Take the train from Bordeaux St Jean to St Jean De Luz CiboureTer
- Take the bus from Saint-Jean-de-Luz to Bilbao Intermodal
- Take the bus from Bilbao Intermodal to Santander E.A.
19h 9mTrain
- Take the train from Mainz, Römisches Theater to Mannheim, HauptbahnhofS5 / ...
- Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhof82 / ...
- Take the train from Strasbourg to Montpellier Saint-RochTgv
- Take the train from Montpellier Saint-Roch to Madrid-Puerta de Atocha-Almudena Grandes
- Take the train from Madrid Chamartín to SantanderAlv / ...
23h 20m€236–592Night train, bus
- Take the night train from Mainz Hbf to Brussel-Zuid / Bruxelles-MidiNj
- Take the bus from Brussels - Midi Train Station to Bilbao Intermodal
- Take the bus from Bilbao Intermodal to Santander E.A.
26h 8m€81–416
Mainz to Santander by train, foot, and bus
Questions & Answers
The cheapest way to get from Mainz to Santander is to bus which costs €65 - €200 and takes 21h 15m.
The fastest way to get from Mainz to Santander is to fly which takes 7h 24m and costs €140 - €290.
No, there is no direct bus from Mainz station to Santander. However, there are services departing from Mainz central train station and arriving at Santander via Paris. The journey, including transfers, takes approximately 21h 15m.
No, there is no direct train from Mainz to Santander. However, there are services departing from Mainz, Römisches Theater and arriving at Santander via Mannheim, Hauptbahnhof, Strasbourg, Montpellier Saint-Roch, Madrid-Atocha Cercanías and Madrid Chamartín. The journey, including transfers, takes approximately 23h 20m.
The distance between Mainz and Santander is 1222 km. The road distance is 1483 km.
The best way to get from Mainz to Santander without a car is to train and bus which takes 17h 37m and costs €180 - €410.
It takes approximately 7h 24m to get from Mainz to Santander, including transfers.
Mainz to Santander bus services, operated by FlixBus, depart from Mainz central train station.
Mainz to Santander train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
The best way to get from Mainz to Santander is to fly which takes 7h 24m and costs €140 - €290. Alternatively, you can bus, which costs €65 - €200 and takes 21h 15m, you could also train, which costs €230 - €600 and takes 23h 20m.
What companies run services between Mainz, Germany and Santander, Spain?
Iberia, Lufthansa, and five other airlines fly from Frankfurt (FRA) to Santander Airport (SDR) 4 times a day. Alternatively, you can take a bus from Mainz central train station to Santander via Paris, Quai de Bercy (Bercy Seine) and Paris in around 21h 15m.
- Website
- iberia.com
Flights from Frankfurt to Santander Airport via Madrid
- Ave. Duration
- 6h 28m
- When
- Every day
- Estimated price
- €85–450
Flights from Frankfurt to Santander Airport via Barcelona
- Ave. Duration
- 5h 45m
- When
- Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €110–440
Flights from Hahn to Santander Airport via Barcelona
- Ave. Duration
- 5h 35m
- When
- Sunday
- Estimated price
- €85–290
- Website
- airfrance.com
Flights from Frankfurt to Bilbao Airport via Paris Charles de Gaulle
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- €55–310
Flights from Frankfurt to Biarritz Pays Basque Airport via Paris Charles de Gaulle
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- €85–460
- Website
- lufthansa.com
Flights from Frankfurt to Bilbao Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- €100–220
Flights from Frankfurt to Biarritz Pays Basque Airport
- Ave. Duration
- 2h
- When
- Saturday
- Estimated price
- €180–600
- Website
- ryanair.com
Flights from Frankfurt to Santander Airport via Birmingham
- Ave. Duration
- 5h 35m
- When
- Monday
- Estimated price
- €80–290
Flights from Hahn to Santander Airport via London Stansted
- Ave. Duration
- 9h 47m
- When
- Friday and Saturday
- Estimated price
- €80–290
- Website
- vueling.com
Flights from Frankfurt to Santander Airport via Barcelona
- Ave. Duration
- 5h 45m
- When
- Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €110–440
Flights from Frankfurt to Santander Airport via Madrid
- Ave. Duration
- 8h
- When
- Every day
- Estimated price
- €110–450
Flights from Hahn to Santander Airport via Barcelona
- Ave. Duration
- 5h 35m
- When
- Sunday
- Estimated price
- €85–290
- Website
- ryanair.com
Flights from Frankfurt to Santander Airport via Manchester
- Ave. Duration
- 5h 20m
- When
- Sunday
- Estimated price
- €90–300
- Website
- airdolomiti.it
Flights from Frankfurt to Biarritz Pays Basque Airport
- Ave. Duration
- 2h
- When
- Saturday
- Estimated price
- €180–600
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mainz, Römisches Theater to Mannheim, Hauptbahnhof
- Ave. Duration
- 53 min
- Frequency
- Twice daily
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Strasbourg Bahnhof
- Ave. Duration
- 1h 9m
- Frequency
- 4 times a day
- Estimated price
- €35–65
- Website
- https://int.bahn.de/en
- Phone
- +33 1 84 94 36 35
- Website
- sncf-connect.com
Train from Strasbourg to Bordeaux St Jean
- Ave. Duration
- 6h 1m
- Frequency
- Once daily
- Estimated price
- €110–260
- Website
- https://www.sncf-connect.com/en-en
Train from Bordeaux St Jean to St Jean De Luz Ciboure
- Ave. Duration
- 2h 13m
- Frequency
- 4 times a day
- Estimated price
- €26–45
- Website
- https://www.sncf-connect.com/en-en
Train from Strasbourg to Montpellier Saint-Roch
- Ave. Duration
- 6h 3m
- Frequency
- Once daily
- Estimated price
- €70–260
- Website
- https://www.sncf-connect.com/en-en
- Phone
- +33 1 84 94 36 35
- Website
- track.effiliation.com
Train from Bordeaux St Jean to St Jean De Luz Ciboure
- Ave. Duration
- 2h 26m
- Frequency
- Every 4 hours
- Estimated price
- €35–80
- Website
- https://track.effiliation.com/servlet/effi.redir?id_compteur=23007591&url=https%3A%2F%2Fwww.sncf-connect.com%2Fen-en%2F
- 2nd Class
- €35–55
- Rail 1st Class
- €55–80
- Phone
- +352 24 89 24 89
- Website
- cfl.lu
Train from Strasbourg to Montpellier Saint-Roch
- Ave. Duration
- 6h 3m
- Frequency
- Once daily
- Estimated price
- €200–300
- Website
- https://www.cfl.lu/en-gb
- 1st Class
- €200–300
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Montpellier Saint-Roch to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 6h 18m
- Frequency
- Once daily
- Estimated price
- €75–110
- Website
- https://www.renfe.com/es/en
Train from Madrid Chamartín to Santander
- Ave. Duration
- 4h 20m
- Frequency
- Twice daily
- Estimated price
- €40–95
- Website
- https://www.renfe.com/es/en
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Mainz Hbf to Brussel-Zuid / Bruxelles-Midi
- Ave. Duration
- 5h 2m
- Frequency
- 5 times a week
- Estimated price
- €40–261
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €259–261
- Couchette Carriage
- €130–160
- Seating Carriage
- €40–55
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Bordeaux to Santander
- Ave. Duration
- 6h 5m
- Frequency
- Once daily
- Estimated price
- €22–60
- Website
- https://www.flixbus.co.uk
Bus from Mainz central train station to Paris, Quai de Bercy (Bercy Seine)
- Ave. Duration
- 7h 25m
- Frequency
- 3 times a day
- Estimated price
- €29–75
- Website
- https://www.flixbus.co.uk
Bus from Paris to Santander
- Ave. Duration
- 12h 50m
- Frequency
- Once daily
- Estimated price
- €40–120
- Website
- https://www.flixbus.co.uk
- Phone
- +34 910 207 007
- alsa@alsa.es
- Website
- alsa.com
Bus from Bilbao Intermodal to Santander E.A.
- Ave. Duration
- 1h 40m
- Frequency
- Hourly
- Estimated price
- €8–15
- Website
- https://www.alsa.com/en/
- info@flibco.com
- Website
- flibco.com
Bus from Mainz Short-term parking lot Am Schlag to Frankfurt Hahn Airport
- Ave. Duration
- 1h 15m
- Frequency
- Every 2 hours
- Estimated price
- €17–20
- Website
- https://www.flibco.com/en
- Website
- blablacar.co.uk
Bus from Biarritz - Airport Bus Station to Bilbao Intermodal
- Ave. Duration
- 2h 20m
- Frequency
- 3 times a day
- Schedules at
- blablacar.co.uk
Bus from Saint-Jean-de-Luz to Bilbao Intermodal
- Ave. Duration
- 2h
- Frequency
- Twice daily
- Schedules at
- blablacar.co.uk
Bus from Brussels - Midi Train Station to Bilbao Intermodal
- Ave. Duration
- 17h 45m
- Frequency
- 3 times a week
- Estimated price
- €30–140
- Website
- https://www.blablacar.co.uk/bus
Want to know more about travelling around Spain
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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More Questions & Answers
Mainz to Santander bus services, operated by FlixBus, arrive at Paris, Quai de Bercy (Bercy Seine) station.
Mainz to Santander train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Mannheim, Hauptbahnhof station.
Yes, the driving distance between Mainz to Santander is 1483 km. It takes approximately 14h 48m to drive from Mainz to Santander.
Book your Mainz to Santander train tickets online with Omio.
Book your Mainz to Santander bus tickets online with Omio and FlixBus.
There are 1984+ hotels available in Santander.





















































