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How to get fromMainz to Santanderby plane, bus, train, car, train (TGV, Renfe) or night train

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There are 8 ways to get from Mainz to Santander by plane, bus, train, car, train (TGV, Renfe), or night train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Frankfurt to Bilbao Airport, bus

    best
    1. Fly from Frankfurt (FRA) to Bilbao Airport (BIO)planeFRA - BIO
    2. Take the bus from Bilbao Intermodal to Santander E.A.bus
    7h 40m
    €111–260
  2. Bus

    cheapest
    1. Take the bus from Mainz central train station to Paris, Quai de Bercy (Bercy Seine)busN90 / ...
    2. Take the bus from Paris to SantanderbusFlixBus 783 / ...
    21h 15m
    €68–157
  3. Train, bus

    1. Take the train from Mainz, Römisches Theater to Mannheim, HauptbahnhoftrainS6
    2. Take the train from Mannheim, Hauptbahnhof to Strasbourg Bahnhoftrain82 / ...
    3. Take the train from Strasbourg to Bordeaux St JeantrainTgv
    4. Take the bus from Bordeaux to Santanderbus
    17h 40m
    €180–390
  4. Drive 1,483 km

    1. Drive from Mainz to Santandercar1,483 km
    14h 48m
    €234–338
  5. Fly Frankfurt to Santander Airport

    1. Fly from Frankfurt (FRA) to Santander Airport (SDR)planeFRA - SDR
    8h 4m
    €151–276
  6. Train to Düsseldorf International Airport, fly to Bilbao Airport, bus

    1. Take the train from Frankfurt to Düsseldorf Hbftrain
    2. Fly from Düsseldorf International Airport (DUS) to Bilbao Airport (BIO)planeDUS - BIO
    3. Take the bus from Bilbao Intermodal to Santander E.A.bus
    9h 41m
    €125–349
  7. Train

    1. Take the train from Frankfurt to Strasbourg Bahnhoftrain82
    2. Take the train from Strasbourg to Montpellier Saint-RochtrainTgv
    3. Take the train from Montpellier Saint-Roch to Madrid-Puerta de Atocha-Almudena Grandestrain
    4. Take the train from Madrid Chamartín to SantandertrainAlv / ...
    23h 26m
    €241–601
  8. Night train, bus

    1. Take the night train from Mainz Hbf to Brussel-Zuid / Bruxelles-MidinighttrainNj
    2. Take the bus from Brussels - Midi Train Station to Bilbao Intermodalbus
    3. Take the bus from Bilbao Intermodal to Santander E.A.bus
    26h 8m
    €81–407

Mainz to Santander by train, foot, and bus

Calendar7Weekly Services
Duration17h 40mAverage Duration
Ticket€180Cheapest Price
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Questions & Answers

What companies run services between Mainz, Germany and Santander, Spain?

You can take a bus from Mainz central train station to Santander via Paris, Quai de Bercy (Bercy Seine) and Paris in around 21h 15m. Alternatively, Iberia, Lufthansa, and five other airlines fly from Frankfurt (FRA) to Santander Airport (SDR) 4 times a day.

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