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How to get fromMaine to Iowaby plane, bus (Amtrak, Flixbus, Greyhound), bus, train, or car

Find Transport to Iowa

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There are 9 ways to get from Maine to Iowa by plane, bus (Amtrak, Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to Des Moines

    best
    1. Fly from Portland (PWM) to Des Moines (DSM)plane plane PWM - DSM
    4h 56m
    $227–952

  2. Fly Portland to Quad City International Airport

    cheapest
    1. Fly from Portland (PWM) to Quad City International Airport (MLI)plane plane PWM - MLI
    7h 16m
    $120–544

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to New York Midtownbus bus
    3. Take the bus from New York Midtown to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    33h 16m
    $241–430

  4. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    33h 39m
    $411–855

  5. Drive 1,352.1 mi

    1. Drive from Portland to Des Moinescar car 1,352.1 mi
    24h 30m
    $247–357

  6. Fly Portland to Omaha

    1. Fly from Portland (PWM) to Omaha (OMA)plane plane PWM - OMA
    5h 15m
    $206–813

  7. Fly Portland to The Eastern Iowa Airport

    1. Fly from Portland (PWM) to The Eastern Iowa Airport (CID)plane plane PWM - CID
    5h 36m
    $163–606

  8. Fly Bangor to Quad City International Airport

    1. Fly from Bangor (BGR) to Quad City International Airport (MLI)plane plane BGR - MLI
    8h 5m
    $144–704

  9. Bus, train via Galesburg

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the train from Boston to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    4. Take the bus from Galesburg to Des Moinesbus bus
    35h 31m
    $441–930

Portland (PWM) to Des Moines (DSM) flights

Calendar77Weekly Planes
Duration6h 41mAverage Duration
Ticket$210Cheapest Price
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Questions & Answers

Map of how to get from Maine to Iowa.ExpandLaunch map view
  • Distance: 1,198.6 mi
  • Duration: 4h 56m

What companies run services between Maine, USA and Iowa, USA?

Southwest Airlines, Delta, and two other airlines fly from Portland (PWM) to Des Moines (DSM) every 2 hours. Alternatively, you can take a bus from Portland Public Library to Des Moines via Portland, ME, Boston, MA - South Station, Boston, New York Midtown, Chicago Bus Station, and Des Moines in around 33h 16m.

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