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How to get fromLyon to Mendrisioby train (Trenitalia), bus, car, plane, train, or train (TGV)

Find Transport to Mendrisio

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There are 8 ways to get from Lyon to Mendrisio by train (Trenitalia), bus, car, plane, train, or train (TGV)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Lyon Part Dieu to Milano Centraletrain train Fr
    2. Take the train from Milano Centrale to Mendrisiotrain train Re80
    6h 18m
    CHF 65–91

  2. Bus, train

    cheapest
    1. Take the bus from Lyon Lyon Perrache Bus Station to Turin Corso Vittorio Emanuele IIbus bus
    2. Take the bus from Turin to Milanbus bus 467 / ...
    3. Take the train from Malpensa Aeroporto T2 to Mendrisio S. Martinotrain train S50
    9h 41m
    CHF 25–47

  3. Bus

    1. Take the bus from Lyon - Gerland Bus Station to Milano, Autostazione Lampugnanobus bus BlaBlaCar Bus
    2. Take the bus from Milan to Comobus bus FlixBus 1524 / ...
    9h 23m
    CHF 27–63

  4. Drive  458.8 km

    1. Drive from Lyon to Mendrisiocar car 458.8 km
    5h 1m
    CHF 77–111

  5. Fly Lyon–Saint Exupéry Airport to Milano Malpensa Airport, train

    1. Fly from Lyon–Saint Exupéry Airport (LYS) to Milano Malpensa Airport (MXP)plane plane LYS - MXP
    2. Take the train from Malpensa Aeroporto T1 to Mendrisiotrain train
    5h 4m
    CHF 74–219

  6. Train via Geneva

    1. Take the train from Lyon Part Dieu to Genevetrain train Ter
    2. Take the train from Genève to Locarnotrain train Ic
    3. Take the train from Locarno to Mendrisiotrain train S
    9h 15m
    CHF 138–235

  7. Train to Geneva International Airport, fly to Zurich Airport, train

    1. Take the train from Lyon Part Dieu to Genevetrain train
    2. Fly from Geneva International Airport (GVA) to Zurich Airport (ZRH)plane plane GVA - ZRH
    3. Take the train from Zürich HB to Luganotrain train
    7h 14m
    CHF 175–448

  8. Fly Lyon–Saint Exupéry Airport to Milan Linate Airport, train

    1. Fly from Lyon–Saint Exupéry Airport (LYS) to Milan Linate Airport (LIN)plane plane LYS - LIN
    2. Take the train from Monza to Mendrisiotrain train
    8h 20m
    CHF 105–254

Lyon to Mendrisio by train

Calendar28Weekly Trains
Duration6h 18mAverage Duration
TicketCHF 65Cheapest Price
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Comparing Your Travel Options

Map of how to get from Lyon to Mendrisio.ExpandLaunch map view
  • Distance: 502.7 km
  • Duration: 6h 18m

What companies run services between Lyon, France and Mendrisio, Switzerland?

You can take a train from Lyon Part Dieu to Mendrisio via Milano Centrale in around 6h 18m. Alternatively, you can take a bus from Lyon - Gerland Bus Station to Mendrisio, Autosilo via Milan, Como, Como - San Rocchetto, and Chiasso, Stazione in around 9h 23m.

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