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How to get fromLexington to St. Louisby car, plane, or bus

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There are 6 ways to get from Lexington to St. Louis by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Louisville International Airport, fly

    best
    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    5h 19m
    $96–572

  2. Drive  337.4 mi

    cheapest
    1. Drive from Lexington to St. Louiscar car 337.4 mi
    5h 46m
    $56–81

  3. Drive, bus

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Evansville, INbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    10h 31m
    $77–197

  4. Drive to Covington, fly

    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    5h 43m
    $147–823

  5. Drive to John Glenn Columbus International Airport, fly

    1. Drive from Lexington to Columbus-Airport-CMHcar car
    2. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    5h 49m
    $166–901

  6. Fly from Blue Grass Airport

    1. Fly from Blue Grass Airport (LEX) to Lambert–St. Louis International Airport (STL)plane plane LEX - STL
    7h 41m
    $100–605

Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL) flights

Calendar121Weekly Planes
Duration4h 36mAverage Duration
Ticket$84Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Lexington to St. Louis.ExpandLaunch map view
  • Distance: 345.9 mi
  • Duration: 5h 19m

What companies run services between Lexington, KY, USA and St. Louis, MO, USA?

Delta, United Airlines, and American Airlines fly from Blue Grass Airport (LEX) to Lambert–St. Louis International Airport (STL) hourly.

Airlines
Bus operators

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