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How to get fromLexington to St. Louisby car, plane or bus

Find Transport to St. Louis

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There are 5 ways to get from Lexington to St. Louis by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Louisville International Airport, fly

    best
    1. Drive from Lexington to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    5h 43m
    $117–724

  2. Drive 337.6 mi

    cheapest
    1. Drive from Lexington to St. Louiscar car 337.6 mi
    5h 45m
    $62–89

  3. Drive, bus

    1. Drive from Lexington to Middletown Station @ Targetcar car
    2. Take the bus from Louisville, KY to Evansville, INbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    10h 40m
    $84–148

  4. Drive to Covington, fly

    1. Drive from Lexington to Covington (CVG)car car
    2. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    5h 47m
    $168–975

  5. Fly from Blue Grass Airport

    1. Fly from Blue Grass Airport (LEX) to Lambert–St. Louis International Airport (STL)plane plane LEX - STL
    7h 49m
    $105–605

Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL) flights

Calendar85Weekly Planes
Duration5h 10mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

What companies run services between Lexington, KY, USA and St. Louis, MO, USA?

Delta, American Airlines, and United Airlines fly from Blue Grass Airport (LEX) to Lambert–St. Louis International Airport (STL) hourly.

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