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How to get fromGainesville to Key Westby plane, bus, ferry, car, shuttle, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Gainesville to Key West by plane, bus, ferry, car, shuttle, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Gainesville Regional Airport

    best
    1. Fly from Gainesville Regional Airport (GNV) to Key West International Airport (EYW)plane plane GNV - EYW
    5h 2m
    $52–274

  2. Bus, ferry

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Naples, FLbus bus Tallahassee
    2. Take the ferry from Marco Island, FL to Key West, FLferry ferry Key West
    11h 23m
    $243–316

  3. Drive 474.4 mi

    1. Drive from Gainesville to Key Westcar car 474.4 mi
    9h 22m
    $87–126

  4. Bus to Orlando, fly

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Orlando - RedCoach Station, FLbus bus
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    4h 53m
    $105–717

  5. Bus to Tampa, fly

    1. Take the bus from Gainesville to Tampa Bus Stationbus bus
    2. Fly from Tampa (TPA) to Key West International Airport (EYW)plane plane TPA - EYW
    5h 34m
    $86–375

  6. Bus to Jacksonville, fly

    1. Take the bus from Gainesville to Jacksonvillebus bus
    2. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    7h 20m
    $372–831

  7. Bus, shuttle

    1. Take the bus from University of Florida - 1956 Gale Lemerand Dr to Kissimmee -1471 East Osceola Parkwaybus bus
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Bayside Marketplacebus bus
    3. Take a shuttle bus from Bayside Marketplace to Plaza Hotelshuttle bus
    14h 31m
    $126–165

  8. Bus

    1. Take the bus from Gainesville to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    15h 11m
    $69–119

Gainesville to Key West by bus and foot

Calendar18Weekly Services
Duration15h 11mAverage Duration
Ticket$69Cheapest Price
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Questions & Answers

Map of how to get from Gainesville to Key West.ExpandLaunch map view
  • Distance: 363 mi
  • Duration: 5h 2m

What companies run services between Gainesville, FL, USA and Key West, FL, USA?

American Airlines and Delta fly from Gainesville Regional Airport (GNV) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Gainesville to N Roosevelt & 3rd Street via Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 15h 11m.

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