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How to get fromDurham to St. Louisby bus, plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

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There are 7 ways to get from Durham to St. Louis by bus, plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 700 bus to Raleigh-Durham International Airport, fly

    best
    1. Take the bus from Pettigrew St at Parking Deck to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    5h 3m
    $138–758

  2. Bus via Columbus

    cheapest
    1. Take the bus from Columbia & Rosemary to Coble Transportation Centerbus bus 4
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus to St Louis Bus Stationbus bus
    24h 57m
    $104–218

  3. Bus

    1. Take the bus from Durham to Atlanta Downtownbus bus FlixBus N2470
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    19h 9m
    $123–246

  4. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 53m
    $413–896

  5. Drive 756 mi

    1. Drive from Durham to St. Louiscar car 756 mi
    13h 42m
    $138–200

  6. Train to Piedmont Triad International Airport, fly

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    6h 52m
    $219–1,027

  7. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    7h 30m
    $203–950

Durham to St. Louis by bus and subway

Calendar5Weekly Services
Duration19h 9mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

Map of how to get from Durham to St. Louis.ExpandLaunch map view
  • Distance: 696.3 mi
  • Duration: 5h 3m

What companies run services between Durham, NC, USA and St. Louis, MO, USA?

You can take a bus from Durham to St Louis Bus Station via Atlanta Downtown, Civic Center Station, Garnett Station, and Atlanta Bus Station in around 19h 9m. Alternatively, you can take a train from Durham Amtrak Station to St. Louis via Raleigh Union Station and Chicago Union Station in around 31h 53m.

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