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How to get fromDurham to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound, Flixbus)

Find Transport to St. Louis

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There are 7 ways to get from Durham to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Raleigh-Durham International Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    5h 9m
    $557–1,108

  2. Bus via Columbus

    cheapest
    1. Take the bus from Durham to Greensboro Bus Stopbus bus
    2. Take the bus from Greensboro to Winston-Salembus bus
    3. Take the bus from Winston Salem to Columbusbus bus
    4. Take the bus from Columbus to St Louis Bus Stationbus bus
    22h 55m
    $119–222

  3. Bus

    1. Take the bus from Durham to Atlanta Downtownbus bus FlixBus N2470
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    19h 19m
    $146–239

  4. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 53m
    $372–968

  5. Drive  756 mi

    1. Drive from Durham to St. Louiscar car 756 mi
    13h 45m
    $138–200

  6. Train to Piedmont Triad International Airport, fly

    1. Take the train from Durham Amtrak Station to Greensborotrain train
    2. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    6h 59m
    $158–731

  7. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    7h 20m
    $139–661

Durham to St. Louis by bus and subway

Calendar4Weekly Services
Duration19h 19mAverage Duration
Ticket$146Cheapest Price
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Comparing Your Travel Options

Map of how to get from Durham to St. Louis.ExpandLaunch map view
  • Distance: 696.4 mi
  • Duration: 5h 9m

What companies run services between Durham, NC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Durham to St Louis Bus Station via Atlanta Downtown, Civic Center Station, Garnett Station, and Atlanta Bus Station in around 19h 19m.

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