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How to get fromDurham to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, train or bus (Greyhound)

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There are 6 ways to get from Durham to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Raleigh-Durham International Airport

    best
    1. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)planeRDU - STL
    5h 1m
    $253–466

  2. Bus via Columbus

    cheapest
    1. Take the bus from Durham to Winston Salem(Trans Center)bus
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus
    3. Take the bus from Columbus to St Louis Bus Stationbus
    22h
    $104–229

  3. Bus

    1. Take the bus from Durham to Atlanta Bus StationbusFlixBus N2470 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus StationbusFlixBus N2521
    18h 40m
    $117–316

  4. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Raleigh Union Stationtrain
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain
    3. Take the train from Chicago Union Station to St. Louistrain
    32h 2m
    $219–1,131

  5. Drive 756 mi

    1. Drive from Durham to St. Louiscar756 mi
    13h 41m
    $138–200

  6. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)planeCLT - STL
    7h 32m
    $251–411

Durham to St. Louis by bus

Calendar7Weekly Buses
Duration18h 40mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

What companies run services between Durham, NC, USA and St. Louis, MO, USA?

Southwest Airlines, American Airlines, and Delta fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Durham to St Louis Bus Station via Atlanta Bus Station in around 18h 40m.

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