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How to get fromDurham to St. Louisby bus, plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

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There are 7 ways to get from Durham to St. Louis by bus, plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Raleigh-Durham International Airport, fly

    best
    1. Take the bus from Durham Station to Regional Transit Centerbus bus
    2. Fly from Raleigh-Durham International Airport (RDU) to Lambert–St. Louis International Airport (STL)plane plane RDU - STL
    4h 59m
    $557–1,008

  2. Bus via Columbus

    cheapest
    1. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    2. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    3. Take the bus from Columbus to St Louis Bus Stationbus bus
    22h
    $113–244

  3. Bus

    1. Take the bus from Durham to Atlanta Bus Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    18h 40m
    $146–285

  4. Train (Amtrak)

    1. Take the train from Durham Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    31h 53m
    $438–907

  5. Drive 756 mi

    1. Drive from Durham to St. Louiscar car 756 mi
    13h 43m
    $138–200

  6. Bus to Piedmont Triad International Airport, fly

    1. Take the bus from Durham to Greensboro Bus Stopbus bus
    2. Fly from Piedmont Triad International Airport (GSO) to Lambert–St. Louis International Airport (STL)plane plane GSO - STL
    6h 50m
    $181–809

  7. Train to Charlotte Douglas International Airport, fly

    1. Take the train from Durham Amtrak Station to Charlotte Amtrak Stationtrain train
    2. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    7h 28m
    $177–755

Durham to St. Louis by bus

Calendar19Weekly Buses
Duration18h 40mAverage Duration
Ticket$146Cheapest Price
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Questions & Answers

Map of how to get from Durham to St. Louis.ExpandLaunch map view
  • Distance: 696.4 mi
  • Duration: 4h 59m

What companies run services between Durham, NC, USA and St. Louis, MO, USA?

You can take a bus from Durham to St Louis Bus Station via Atlanta Bus Station in around 18h 40m. Alternatively, you can take a train from Durham Amtrak Station to St. Louis via Raleigh Union Station and Chicago Union Station in around 31h 53m.

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