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How to get fromDes Moines to Key Largoby plane, shuttle, bus (Flixbus, Greyhound), bus, train or car

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There are 6 ways to get from Des Moines to Key Largo by plane, shuttle, bus (Flixbus, Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Fort Lauderdale–Hollywood International Airport, shuttle

    best
    1. Fly from Des Moines (DSM) to Fort Lauderdale–Hollywood International Airport (FLL)planeDSM - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle
    6h 6m
    $238–761

  2. Bus

    cheapest
    1. Take the bus from Des Moines to Chicagobus
    2. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus
    4. Take the bus from Miami Airport Station to Key Largo Bus Stopbus
    39h 10m
    $222–586

  3. Bus, train, shuttle

    1. Take the bus from Des Moines to Chicagobus
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle
    2d 9h
    $413–997

  4. Drive 1,582.2 mi

    1. Drive from Des Moines to Key Largocar1,582.2 mi
    27h 48m
    $289–418

  5. Fly to Miami International Airport, shuttle

    1. Fly from Des Moines (DSM) to Miami International Airport (MIA)planeDSM - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle
    5h 57m
    $258–931

  6. Fly to Key West International Airport, bus

    1. Fly from Des Moines (DSM) to Key West International Airport (EYW)planeDSM - EYW
    2. Take the bus from Key West Airport to Key Largo Bus Stopbus
    8h 51m
    $249–1,056

Des Moines to Key Largo by bus

Calendar7Weekly Buses
Duration39h 10mAverage Duration
Ticket$222Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Key Largo, FL, USA?

You can take a bus from Des Moines to Key Largo Bus Stop via Chicago Bus Station, Atlanta Bus Station, and Miami Airport Station in around 39h 10m.

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