There are 6 ways to get from Des Moines to San Diego by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Des Moines  •  7 h 7 min

  1. DSM - SAN

$284 - $1,205

Cheapest option

Bus  •  41 h 32 min

  1. 803 / ...

$208 - $475

4 alternative options

Bus to Omaha, fly  •  8 h 29 min

  1. OMA - SAN

$248 - $952

Bus, train  •  41 h 35 min

  1. 803 / ...

$297 - $829

Bus via Denver, CO  •  41 h 55 min

$225 - $436

Drive  •  27 h 15 min

  1. 1780.3 miles

$170 - $260

What companies run services between Des Moines, IA, USA and San Diego, CA, USA?

Southwest Airlines, United Airlines and two other airlines fly from Des Moines to San Diego hourly. Alternatively, you can take a bus from Des Moines to San Diego via Kansas City, MO, Kansas City, Mo, and Los Angeles, Ca in around 41 h 32 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Des Moines to San Diego via Las Vegas
Ave. Duration
6 h 18 min
When
Every day
Estimated price
$310 - $1,200
Flights from Des Moines to San Diego via St. Louis
Ave. Duration
6 h 30 min
When
Monday to Friday
Estimated price
$350 - $1,300
Flights from Omaha to San Diego via Las Vegas
Ave. Duration
5 h 11 min
When
Monday to Saturday
Estimated price
$260 - $1,000
Flights from Omaha to San Diego via Denver
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$260 - $1,000
Flights from Omaha to San Diego via Phoenix
Ave. Duration
5 h 2 min
When
Every day
Estimated price
$260 - $1,000
United Airlines
Website
united.com
Flights from Des Moines to San Diego via Denver
Ave. Duration
6 h 5 min
When
Every day
Estimated price
$280 - $1,300
Flights from Des Moines to San Diego via Chicago O'Hare
Ave. Duration
7 h 24 min
When
Every day
Estimated price
$330 - $1,400
Flights from Des Moines to San Diego via Houston
Ave. Duration
6 h 58 min
When
Every day
Estimated price
$330 - $1,400
Flights from Omaha to San Diego via Denver
Ave. Duration
5 h 16 min
When
Every day
Estimated price
$230 - $1,100
Delta
Website
delta.com
Flights from Des Moines to San Diego via Minneapolis
Ave. Duration
6 h 26 min
When
Every day
Estimated price
$280 - $1,300
Flights from Des Moines to San Diego via Detroit
Ave. Duration
7 h 47 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$340 - $1,400
Flights from Des Moines to San Diego via Atlanta
Ave. Duration
7 h 53 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$350 - $1,400
Flights from Omaha to San Diego via Salt Lake City
Ave. Duration
5 h 34 min
When
Every day
Estimated price
$220 - $1,000
American Airlines
Website
aa.com
Flights from Des Moines to San Diego via Phoenix
Ave. Duration
5 h 45 min
When
Every day
Estimated price
$280 - $1,200
Flights from Des Moines to San Diego via Dallas/Ft.Worth
Ave. Duration
6 h 21 min
When
Every day
Estimated price
$310 - $1,200
Flights from Des Moines to San Diego via Chicago O'Hare
Ave. Duration
6 h 50 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$330 - $1,300
Flights from Omaha to San Diego via Phoenix
Ave. Duration
5 h 2 min
When
Every day
Estimated price
$230 - $1,000
Flights from Omaha to San Diego via Los Angeles
Ave. Duration
5 h 18 min
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$240 - $1,000
Alaska Airlines, Inc.
Website
alaskaair.com
Flights from Des Moines to San Diego via Chicago O'Hare
Ave. Duration
6 h 50 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$330 - $1,300
Flights from Omaha to San Diego
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$210 - $900
Flights from Omaha to San Diego via Los Angeles
Ave. Duration
5 h 18 min
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$240 - $1,000
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Kansas City Amtrak to Fullerton Transportation Center
Ave. Duration
33 h 59 min
Frequency
Twice daily
Estimated price
$220 - $700
Website
amtrak.com
Coach Seat
$220 - $330
Flexi Coach Seat
$390 - $600
Business Coach Seat
$470 - $700
Room
$850 - $1,200
Train from Fullerton Transportation Center to San Diego Santa Fe Depot Amtrak
Ave. Duration
2 h 23 min
Frequency
Every 2 hours
Estimated price
$30 - $65
Website
amtrak.com
Coach Seat
$30 - $45
Flexi Coach Seat
$50 - $80
Business Coach Seat
$45 - $65
Room
$160 - $220
Bus operators
Burlington Trailways
Website
burlingtontrailways.com
Bus from Des Moines, IA to Omaha, NE
Ave. Duration
2 h 10 min
Frequency
Hourly
Estimated price
$30 - $50
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Des Moines, IA to Denver, CO
Ave. Duration
14 h 15 min
Frequency
Once daily
Estimated price
$90 - $130
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Des Moines, IA to Kansas City, MO
Ave. Duration
3 h 10 min
Frequency
Hourly
Estimated price
$40 - $55
Schedules at
jeffersonlines.com
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Kansas City, Mo to Los Angeles, Ca
Ave. Duration
34 h 35 min
Frequency
Hourly
Estimated price
$150 - $380
Website
greyhound.com
Economy
$150 - $250
Flexible
$290 - $380
Bus from Los Angeles, Ca to San Diego, Ca
Ave. Duration
2 h 20 min
Frequency
Hourly
Estimated price
$17 - $40
Website
greyhound.com
Economy
$17 - $26
Flexible
$30 - $40
Bus from Denver, Co to Los Angeles, Ca
Ave. Duration
21 h 45 min
Frequency
Hourly
Estimated price
$95 - $250
Website
greyhound.com
Economy
$95 - $160
Flexible
$190 - $250
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from Los Angeles to San Diego
Ave. Duration
4 h 10 min
Frequency
Twice daily
Estimated price
$40 - $60
Schedules at
greyhound.com.mx

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Questions & Answers

The distance between Des Moines and San Diego is 2299 km. The road distance is 2849 km.

The cheapest way to get from Des Moines to San Diego is to drive which costs $170 - $260 and takes 27 h 15 min.

The quickest way to get from Des Moines to San Diego is to fly which takes 7 h 7 min and costs $280 - $1,200.

No, there is no direct bus from Des Moines to San Diego. However, there are services departing from Des Moines, IA and arriving at San Diego, Ca via Kansas City, Mo and Los Angeles, Ca. The journey, including transfers, takes approximately 41 h 32 min.

It takes approximately 7 h 7 min to get from Des Moines to San Diego, including transfers.