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How to get fromDes Moines to San Diegoby plane, bus (Greyhound, Flixbus), bus, train or car

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There are 4 ways to get from Des Moines to San Diego by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to San Diego International Airport (SAN)planeDSM - SAN
    5h 27m
    $228–1,021

  2. Bus, train

    cheapest
    1. Take the bus from Des Moines to Kansas Citybus
    2. Take the train from Kansas City to Fullerton Amtrak Stationtrain
    3. Take the train from Fullerton Amtrak Station to San Diegotrain
    43h 26m
    $201–602

  3. Bus

    1. Take the bus from Des Moines to Denverbus
    2. Take the bus from Denver Union Station to South Strip Transit Terminalbus
    3. Take the bus from South Strip Transit Terminal to Santa Ana Bus Stopbus
    4. Take the bus from Santa Ana Bus Stop to San Diegobus
    39h 27m
    $224–520

  4. Drive 1,745.2 mi

    1. Drive from Des Moines to San Diegocar1,745.2 mi
    26h 56m
    $319–460

Des Moines to San Diego by bus and foot

Calendar7Weekly Services
Duration39h 27mAverage Duration
Ticket$224Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and San Diego, CA, USA?

Southwest Airlines, United Airlines, and three other airlines fly from Des Moines (DSM) to San Diego International Airport (SAN) hourly. Alternatively, you can take a bus from Des Moines to San Diego via Denver, Denver Union Station, South Strip Transit Terminal, and Santa Ana Bus Stop in around 39h 27m.

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