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How to get fromDes Moines to Durhamby plane, bus (Greyhound, Flixbus), bus, train or car

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There are 7 ways to get from Des Moines to Durham by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Raleigh-Durham International Airport

    best
    1. Fly from Des Moines (DSM) to Raleigh-Durham International Airport (RDU)plane plane DSM - RDU
    5h 55m
    $148–724

  2. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Washington Union Stationbus bus
    3. Take the bus from Washington Union Station to Durhambus bus
    31h 45m
    $210–437

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0155S
    2. Take the train from Chicago Union Station to Carytrain train Floridian
    35h 22m
    $360–812

  4. Drive 1,053.4 mi

    1. Drive from Des Moines to Durhamcar car 1,053.4 mi
    18h 15m
    $193–278

  5. Fly to Piedmont Triad International Airport, train

    1. Fly from Des Moines (DSM) to Piedmont Triad International Airport (GSO)plane plane DSM - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    6h 51m
    $232–1,041

  6. Fly to Charlotte Douglas International Airport, train

    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the train from Charlotte Amtrak Station to Durham Amtrak Stationtrain train
    7h 23m
    $172–767

  7. Bus, train via Saint Paul

    1. Take the bus from Des Moines to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Carytrain train
    39h 53m
    $439–1,065

Des Moines to Durham by bus

Calendar7Weekly Buses
Duration31h 45mAverage Duration
Ticket$210Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Durham, NC, USA?

Southwest Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Raleigh-Durham International Airport (RDU) hourly. Alternatively, you can take a bus from Des Moines to Durham via Chicago Bus Station and Washington Union Station in around 31h 45m.

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