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How to get fromChicago to Durhamby plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, subway, or train

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There are 6 ways to get from Chicago to Durham by plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, subway, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Raleigh-Durham International Airport, bus, line 700 bus

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Raleigh-Durham International Airport (RDU)plane plane ORD - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Pettigrew St at Parking Deckbus bus
    5h 19m
    $172–458

  2. Subway to Chicago Midway International Airport, fly to Raleigh-Durham International Airport, bus, line 700 bus

    cheapest
    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Raleigh-Durham International Airport (RDU)plane plane MDW - RDU
    3. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    4. Take the bus from Regional Transit Center to Pettigrew St at Parking Deckbus bus
    4h 57m
    $98–558

  3. Bus

    1. Take the bus from Chicago Bus Station to Washington Union Stationbus bus Greyhound US0164
    2. Take the bus from Washington Union Station to Durhambus bus FlixBus N2471 / ...
    22h 40m
    $141–295

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Carytrain train Floridian
    26h 13m
    $317–671

  5. Drive 752.6 mi

    1. Drive from Chicago to Durhamcar car 752.6 mi
    14h 4m
    $138–199

  6. Fly Chicago O'Hare International Airport to Piedmont Triad International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Piedmont Triad International Airport (GSO)plane plane ORD - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    6h 4m
    $132–565

Chicago to Durham by bus

Calendar14Weekly Buses
Duration22h 40mAverage Duration
Ticket$141Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Durham, NC, USA?

You can take a bus from Chicago Bus Station to Durham via Washington Union Station in around 22h 40m. Alternatively, Amtrak operates a train from Chicago Union Station to Cary once daily. Tickets cost $310–700 and the journey takes 24h 26m.

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