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How to get fromChicago to Durhamby subway, plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, or train

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There are 6 ways to get from Chicago to Durham by subway, plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Chicago Midway International Airport, fly to Raleigh-Durham International Airport, bus, line 700 bus

    best
    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Raleigh-Durham International Airport (RDU)plane plane MDW - RDU
    3. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    4. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    4h 53m
    $158–311

  2. Drive 752.5 mi

    cheapest
    1. Drive from Chicago to Durhamcar car 752.5 mi
    14h 5m
    $138–199

  3. Bus

    1. Take the bus from Chicago Bus Station to Washington Union Stationbus bus Greyhound US0164
    2. Take the bus from Washington Union Station to Durhambus bus FlixBus N2471 / ...
    23h 14m
    $148–289

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Carytrain train Floridian
    26h 13m
    $345–713

  5. Fly Chicago O'Hare International Airport to Raleigh-Durham International Airport, bus, line 700 bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Raleigh-Durham International Airport (RDU)plane plane ORD - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    5h 16m
    $178–761

  6. Fly Chicago O'Hare International Airport to Piedmont Triad International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Piedmont Triad International Airport (GSO)plane plane ORD - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    6h 3m
    $148–680

Chicago to Durham by bus

Calendar28Weekly Buses
Duration23h 14mAverage Duration
Ticket$148Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Durham.ExpandLaunch map view
  • Distance: 658.8 mi
  • Duration: 4h 53m

What companies run services between Chicago, IL, USA and Durham, NC, USA?

You can take a bus from Chicago Bus Station to Durham via Washington Union Station in around 23h 14m. Alternatively, Amtrak operates a train from Chicago Union Station to Cary once daily. Tickets cost $330–750 and the journey takes 24h 26m.

Airlines
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