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How to get fromChicago to Durhamby subway, plane, bus, bus (Greyhound), train (Amtrak) or car

Find Transport to Durham

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There are 5 ways to get from Chicago to Durham by subway, plane, bus, bus (Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Chicago Midway International Airport, fly, bus, line 700 bus

    best
    1. Take the subway from Roosevelt to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Raleigh-Durham International Airport (RDU)plane plane MDW - RDU
    3. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    4. Take the bus from Regional Transit Center to Durham Station Gate Jbus bus
    4h 58m
    $92–558

  2. Fly from Chicago O'Hare International Airport, bus, line 700 bus

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Raleigh-Durham International Airport (RDU)plane plane ORD - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Durham Station Gate Jbus bus
    5h 27m
    $88–368

  3. Bus

    1. Take the bus from Chicago Bus Station to Toledo Bus Stopbus bus
    2. Take the bus from Toledo Bus Stop to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    21h 40m
    $102–253

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Carytrain train Floridian
    25h 39m
    $149–313

  5. Drive 752.6 mi

    1. Drive from Chicago to Durhamcar car 752.6 mi
    14h 4m
    $138–199

Chicago to Durham by bus

Calendar7Weekly Buses
Duration21h 40mAverage Duration
Ticket$102Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Durham, NC, USA?

You can take a bus from Chicago Bus Station to Durham via Toledo Bus Stop and Winston Salem(Trans Center) in around 21h 40m. Alternatively, Amtrak operates a train from Chicago Union Station to Cary once daily. Tickets cost $140–310 and the journey takes 24h 21m.

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