There are 7 ways to get from Des Moines to Cheyenne by plane, bus, car, taxi, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Cheyenne Airport
best- Fly from Des Moines (DSM) to Cheyenne Airport (CYS)DSM - CYS
5h 13m$128–671Bus #2
cheapest- Take the bus from Des Moines to Denver Union StationGreyhound US0123
- Take the bus from Denver Union Station to CheyenneGreyhound US0560S
18h 5m$95–233Bus via Omaha
- Take the bus from Des Moines to Omaha
- Take the bus from Omaha, NE to Denver
- Take the bus from Denver International Airport Pickups to Warren AFB
17h 46m$227–330Drive 627.6 mi
- Drive from Des Moines to Cheyenne627.6 mi
9h 39m$115–166Fly to Laramie Regional Airport, taxi
- Fly from Des Moines (DSM) to Laramie Regional Airport (LAR)DSM - LAR
- Take the taxi from Laramie-Airport-LAR to Cheyenne
5h 42m$228–791Fly to Denver, bus
- Fly from Des Moines (DSM) to Denver (DEN)DSM - DEN
- Take the bus from Denver International Airport Pickups to Warren AFB
5h 32m$218–961Bus
- Take the bus from Des Moines to DenverIndianapolis
- Take the bus from Denver International Airport Pickups to Warren AFBGroome Transportation - Wyoming
17h 54m$173–320
Des Moines to Cheyenne by bus
Questions & Answers
The cheapest way to get from Des Moines to Cheyenne is to drive which costs $110 - $170 and takes 9h 39m.
The fastest way to get from Des Moines to Cheyenne is to fly which takes 5h 13m and costs $120 - $700.
No, there is no direct bus from Des Moines to Cheyenne. However, there are services departing from Des Moines and arriving at Cheyenne Regional Medical Center via Denver Union Station and Greyhound. The journey, including transfers, takes approximately 18h 5m.
The distance between Des Moines and Cheyenne is 590 miles. The road distance is 631.2 miles.
The best way to get from Des Moines to Cheyenne without a car is to bus via Omaha which takes 17h 46m and costs $220 - $330.
It takes approximately 5h 13m to get from Des Moines to Cheyenne, including transfers.
Des Moines to Cheyenne bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Cheyenne is to fly which takes 5h 13m and costs $120 - $700. Alternatively, you can bus via Omaha, which costs $220 - $330 and takes 17h 46m.
Des Moines to Cheyenne bus services, operated by Greyhound USA, arrive at Denver Union Station.
Cheyenne is 1h behind Des Moines. It is currently 1:22 PM in Des Moines and 12:22 PM in Cheyenne.
What companies run services between Des Moines, IA, USA and Cheyenne, WY, USA?
United Airlines and Southwest Airlines fly from Des Moines (DSM) to Cheyenne Airport (CYS) 3 times a day. Alternatively, you can take a bus from Des Moines to Warren AFB via Omaha, NE, Denver, Union Station, Denver Airport Station, and Denver International Airport Pickups in around 17h 46m.
- Website
- united.com
Flights from Des Moines to Cheyenne Airport via Denver
- Ave. Duration
- 5h 31m
- When
- Every day
- Estimated price
- $110–650
Flights from Des Moines to Cheyenne Airport via Chicago O'Hare, Denver
- Ave. Duration
- 7h 45m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $170–800
Flights from Des Moines to Laramie Regional Airport via Denver
- Ave. Duration
- 6h 17m
- When
- Every day
- Estimated price
- $110–650
Flights from Des Moines to Denver
- Ave. Duration
- 2h 16m
- When
- Every day
- Estimated price
- $150–850
- Website
- flyfrontier.com
Flights from Des Moines to Denver
- Ave. Duration
- 2h 11m
- When
- Monday, Tuesday, Friday, and Saturday
- Estimated price
- $150–850
- Website
- southwest.com
Flights from Des Moines to Denver
- Ave. Duration
- 2h 7m
- When
- Every day
- Estimated price
- $150–850
- Website
- delta.com
Flights from Des Moines to Denver via Minneapolis
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $190–1,000
- Phone
- +1 (319) 753-2864
- info@burlingtontrailways.com
- Website
- burlingtontrailways.com
Bus from Des Moines to Omaha
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $35–70
- Website
- https://burlingtontrailways.com
- Saver Fares
- $35–55
- Flexible Fares
- $45–70
Bus from Des Moines to Denver
- Ave. Duration
- 13h 25m
- Frequency
- Once daily
- Estimated price
- $110–220
- Website
- https://burlingtontrailways.com
- Saver Fares
- $110–160
- Flexible Fares
- $150–220
- Phone
- +1-877-779-2999
- tony@expressarrow.com
- Website
- expressarrow.com
Bus from Omaha, NE to Denver
- Ave. Duration
- 10h 20m
- Frequency
- Once daily
- Estimated price
- $130–160
- Website
- https://expressarrow.com
Bus from Denver Union Station to Cheyenne
- Ave. Duration
- 2h 15m
- Frequency
- 4 times a week
- Estimated price
- $45–55
- Website
- https://expressarrow.com
- Phone
- +1 970-226-5533
- Website
- groometransportation.com
Bus from Denver International Airport Pickups to Warren AFB
- Ave. Duration
- 2h 20m
- Frequency
- Every 4 hours
- Estimated price
- $50–90
- Website
- https://groometransportation.com/denver-airport
- Schedules at
- https://groometransportation.com/wyoming
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Des Moines to Denver Union Station
- Ave. Duration
- 14h 5m
- Frequency
- Once daily
- Estimated price
- $65–180
- Website
- https://www.greyhound.com/
Bus from Denver Union Station to Cheyenne
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $29–60
- Website
- https://www.greyhound.com/
- Ave. Duration
- 55 min
- Estimated price
- $100–120
Snowy Range Taxi
- Phone
- +1-307-343-2323
- Website
- snowyrangetaxi.com
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More Questions & Answers
Yes, the driving distance between Des Moines to Cheyenne is 631 miles. It takes approximately 9h 39m to drive from Des Moines to Cheyenne.
There are 60+ hotels available in Cheyenne.







