Rome2Rio

How to get fromDes Moines to Defianceby plane, taxi, bus (Greyhound, Amtrak), bus, train, or car

Find Transport to Defiance

See all options

There are 5 ways to get from Des Moines to Defiance by plane, taxi, bus (Greyhound, Amtrak), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, taxi

    best
    1. Fly from Des Moines (DSM) to Fort Wayne International Airport (FWA)plane plane DSM - FWA
    2. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    4h 59m
    $238–701

  2. Drive 511.4 mi

    cheapest
    1. Drive from Des Moines to Defiancecar car 511.4 mi
    9h 26m
    $94–135

  3. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the bus from Chicago Union Station to Bryan Amtrak Stationbus bus Amtrak Thruway Connecting Service
    11h 57m
    $165–268

  4. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train
    13h 23m
    $181–341

  5. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    11h 57m
    $155–278

Des Moines (DSM) to Fort Wayne International Airport (FWA) flights

Calendar92Weekly Planes
Duration5h 34mAverage Duration
Ticket$83Cheapest Price
See schedules

Questions & Answers

Map of how to get from Des Moines to Defiance.ExpandLaunch map view
  • Distance: 500.5 mi
  • Duration: 4h 59m

What companies run services between Des Moines, IA, USA and Defiance, OH, USA?

You can take a bus from Des Moines to Defiance via Chicago Bus Station, Chicago Union Station, and Bryan Amtrak Station in around 11h 57m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound