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How to get fromDes Moines to Defianceby plane, taxi, bus, train or car

Find Transport to Defiance

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There are 7 ways to get from Des Moines to Defiance by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, taxi

    best
    1. Fly from Des Moines (DSM) to Fort Wayne International Airport (FWA)planeDSM - FWA
    2. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi
    4h 55m
    $238–691

  2. Drive 511.4 mi

    cheapest
    1. Drive from Des Moines to Defiancecar511.4 mi
    9h 22m
    $94–135

  3. Bus, train

    1. Take the bus from Des Moines to ChicagobusOmaha
    2. Take the train from Chicago Union Station to Bryan Amtrak StationtrainLake Shore Limited
    11h 2m
    $163–283

  4. Bus, train via Galesburg

    1. Take the bus from Des Moines to Burlingtonbus
    2. Take the bus from Burlington to Galesburgbus
    3. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
    4. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain
    13h 38m
    $181–337

  5. Bus, train via Des Moines

    1. Take the bus from Des Moines to ChicagobusDes Moines
    2. Take the train from Chicago Union Station to Bryan Amtrak StationtrainLake Shore Limited
    12h 7m
    $151–294

  6. Bus, train via Des Moines #2

    1. Take the bus from Des Moines to Chicago Bus StationbusGreyhound US0123 / ...
    2. Take the train from Chicago Union Station to Bryan Amtrak StationtrainLake Shore Limited
    12h 47m
    $140–219

  7. Bus, taxi

    1. Take the bus from Des Moines to Chicagobus
    2. Take the bus from Chicago to Van Wertbus
    3. Take the taxi from Van Wert to Defiancetaxi
    12h 57m
    $178–323

Des Moines (DSM) to Fort Wayne International Airport (FWA) flights

Calendar83Weekly Planes
Duration5h 30mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Defiance, OH, USA?

There is no direct connection from Des Moines to Defiance. However, you can take the taxi to Des Moines (DSM) airport, fly to Fort Wayne International Airport (FWA), then take the taxi to Defiance. Alternatively, you can take a bus from Des Moines to Defiance via Chicago, Chicago Union Station, and Bryan Amtrak Station in around 11h 2m.

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