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How to get fromDes Moines to Defianceby plane, taxi, bus, train or car

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There are 7 ways to get from Des Moines to Defiance by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, taxi

    best
    1. Fly from Des Moines (DSM) to Fort Wayne International Airport (FWA)plane plane DSM - FWA
    2. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    5h 20m
    $253–801

  2. Drive 511.4 mi

    cheapest
    1. Drive from Des Moines to Defiancecar car 511.4 mi
    9h 22m
    $94–135

  3. Bus, train

    1. Take the bus from Des Moines to Chicagobus bus Omaha
    2. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    11h 2m
    $153–293

  4. Bus, train via Galesburg

    1. Take the bus from Des Moines to Burlingtonbus bus
    2. Take the bus from Burlington to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    4. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train
    13h 38m
    $175–357

  5. Bus, train via Des Moines

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    11h 57m
    $142–250

  6. Bus, train via Des Moines #2

    1. Take the bus from Des Moines to Chicagobus bus Des Moines
    2. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    12h 7m
    $141–304

  7. Bus, taxi

    1. Take the bus from Des Moines to Chicagobus bus
    2. Take the bus from Chicago to Van Wertbus bus
    3. Take the taxi from Van Wert to Defiancetaxi taxi
    12h 57m
    $178–323

Des Moines (DSM) to Fort Wayne International Airport (FWA) flights

Calendar65Weekly Planes
Duration5h 36mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Defiance, OH, USA?

There is no direct connection from Des Moines to Defiance. However, you can take the taxi to Des-Moines-Airport-DSM airport, fly to Fort Wayne International Airport (FWA), then take the taxi to Defiance. Alternatively, you can take a bus from Des Moines to Defiance via Chicago, Chicago Union Station, and Bryan Amtrak Station in around 11h 2m.

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