There are 6 ways to get from Cheyenne to Des Moines by plane, bus, car, taxi, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Cheyenne Airport
best- Fly from Cheyenne Airport (CYS) to Des Moines (DSM)CYS - DSM
4h 21m$160–787Drive 628.4 mi
cheapest- Drive from Cheyenne to Des Moines628.4 mi
9h 37m$115–166Bus
- Take the bus from Warren AFB to Denver International Airport PickupsGroome Transportation - Wyoming
- Take the bus from Denver to Des MoinesDenver
16h 14m$173–331Taxi to Laramie Regional Airport, fly
- Take the taxi from Cheyenne to Laramie Regional Airport (LAR)
- Fly from Laramie Regional Airport (LAR) to Des Moines (DSM)LAR - DSM
5h 24m$247–889Bus to Denver, fly
- Take the bus from Warren AFB to Denver International Airport Pickups
- Fly from Denver (DEN) to Des Moines (DSM)DEN - DSM
5h 11m$200–862Bus via Des Moines
- Take the bus from Warren AFB to Denver International Airport PickupsGroome Transportation - Wyoming
- Take the bus from Denver Union Station to Des MoinesGreyhound US0123
17h 11m$138–221
Cheyenne Airport (CYS) to Des Moines (DSM) flights
Questions & Answers
The cheapest way to get from Cheyenne to Des Moines is to drive which costs $110 - $170 and takes 9h 37m.
The fastest way to get from Cheyenne to Des Moines is to fly which takes 4h 21m and costs $160 - $800.
The distance between Cheyenne and Des Moines is 592 miles. The road distance is 632.1 miles.
The best way to get from Cheyenne to Des Moines without a car is to bus which takes 16h 14m and costs $170 - $340.
It takes approximately 4h 21m to get from Cheyenne to Des Moines, including transfers.
The best way to get from Cheyenne to Des Moines is to fly which takes 4h 21m and costs $160 - $800. Alternatively, you can bus, which costs $170 - $340 and takes 16h 14m.
Des Moines is 1h ahead of Cheyenne. It is currently 8:13 PM in Cheyenne and 9:13 PM in Des Moines.
Yes, the driving distance between Cheyenne to Des Moines is 632 miles. It takes approximately 9h 37m to drive from Cheyenne to Des Moines.
There are 223+ hotels available in Des Moines.
What companies run services between Cheyenne, WY, USA and Des Moines, IA, USA?
United Airlines flies from Cheyenne Airport (CYS) to Des Moines (DSM) once daily. Alternatively, you can take a bus from Warren AFB to Des Moines via Denver International Airport Pickups, Denver Airport Station, Union Station, and Denver in around 16h 14m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- united.com
Flights from Cheyenne Airport to Des Moines via Denver
- Ave. Duration
- 5h 6m
- When
- Every day
- Estimated price
- $130–750
Flights from Laramie Regional Airport to Des Moines via Denver
- Ave. Duration
- 6h 1m
- When
- Every day
- Estimated price
- $130–750
Flights from Denver to Des Moines
- Ave. Duration
- 1h 47m
- When
- Every day
- Estimated price
- $130–750
- Website
- southwest.com
Flights from Denver to Des Moines
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $130–750
Flights from Denver to Des Moines via St. Louis
- Ave. Duration
- 4h 20m
- When
- Monday to Wednesday
- Estimated price
- $190–950
- Website
- flyfrontier.com
Flights from Denver to Des Moines
- Ave. Duration
- 1h 45m
- When
- Tuesday, Wednesday, Friday, and Sunday
- Estimated price
- $130–750
- Website
- delta.com
Flights from Denver to Des Moines via Minneapolis
- Ave. Duration
- 4h 15m
- When
- Friday
- Estimated price
- $170–900
- Phone
- +1 970-226-5533
- Website
- groometransportation.com
Bus from Warren AFB to Denver International Airport Pickups
- Ave. Duration
- 2h 20m
- Frequency
- Every 4 hours
- Estimated price
- $50–95
- Website
- https://groometransportation.com/denver-airport
- Schedules at
- https://groometransportation.com/wyoming
- Phone
- +1 (319) 753-2864
- info@burlingtontrailways.com
- Website
- burlingtontrailways.com
Bus from Denver to Des Moines
- Ave. Duration
- 11h 45m
- Frequency
- Once daily
- Estimated price
- $110–230
- Website
- https://burlingtontrailways.com
- Saver Fares
- $110–160
- Flexible Fares
- $150–230
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Denver Union Station to Des Moines
- Ave. Duration
- 12h 55m
- Frequency
- Once daily
- Estimated price
- $75–120
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide





