COVID-19 Travel restrictions may apply in United States. Learn More.

There are 5 ways to get from Boston to St Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Boston  •  4h 41m

  1. Fly from Boston (BOS) to St. Louis (STL) BOS - STL

$80 - $296

4 alternative options

Bus to Hartford, fly  •  7h 56m

  1. Take the bus from South Station, Boston, MA to Union Station, Hartford, CT
  2. Fly from Hartford (BDL) to St. Louis (STL) BDL - STL

$141 - $267

Bus  •  28h 11m

  1. Take the bus from Boston South Buses to Newark Penn Station Boston / ...
  2. Take the bus from Newark to St Louis "Greyhound"

$121 - $179

Train  •  28h 30m

  1. Take the train from Boston South Station to Chicago Union Station Lake Shore Limited
  2. Take the train from Chicago Union Station to St. Louis Lincoln Service / ...

$143 - $203

Drive  •  19h 41m

  1. Drive from Boston to St Louis 1183.8 miles

$110 - $170

Boston → St Louis
Fully open

Travel safe during COVID-19

Rules to follow in United States

2m

Regional advice

Travel within United States

Domestic border crossings may be subject to approval, testing and quarantine

COVID-19 help in United States

If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 800-232-4636

Frequently Asked Questions


Yes, travel within United States is currently allowed.

Explore travel options

Domestic travel is not restricted, but some conditions may apply

  • Face masks are recommended
  • There is a social distancing requirement of 2 metres
  • Domestic border crossings may be subject to approval, testing and quarantine

Explore travel options

The national COVID-19 helpline number in St Louis is 800-232-4636.

Wearing a face mask on public transport in St Louis is subject to regional advice.

The social distance requirement in St Louis is 2 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800-232-4636.

Last updated: 4 May 2021
Exceptions may apply, for full details: Centers for Disease control and prevention (CDC).

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The most affordable way to get from Boston to St Louis is to drive, which costs $110 - $170 and takes 19h 41m.

More details

The quickest way to get from Boston to St Louis is to fly which costs $75 - $300 and takes 4h 41m.

More details

No, there is no direct bus from Boston to St Louis. However, there are services departing from Boston South Buses and arriving at St Louis via Newark. The journey, including transfers, takes approximately 28h 11m.

More details

No, there is no direct train from Boston station to St Louis. However, there are services departing from Boston South Station and arriving at St. Louis via Chicago Union Station. The journey, including transfers, takes approximately 28h 30m.

More details

The distance between Boston and St Louis is 1042 miles. The road distance is 1183.8 miles.

Get driving directions

The best way to get from Boston to St Louis without a car is to bus which takes 28h 11m and costs $120 - $180.

More details

It takes approximately 4h 41m to get from Boston to St Louis, including transfers.

More details

Boston to St Louis bus services, operated by Boltbus, depart from Boston South Buses station.

More details

Boston to St Louis train services, operated by Amtrak, depart from Boston South Station.

More details

The best way to get from Boston to St Louis is to fly which takes 4h 41m and costs $75 - $300. Alternatively, you can bus, which costs $120 - $180 and takes 28h 11m, you could also train, which costs $140 - $210 and takes 28h 30m.

Mode details

Map of how to get from Boston to St Louis.
Launch map view
  • Distance: 1041.7 miles
  • Duration: 4h 41m

What companies run services between Boston, MA, USA and St Louis, MO, USA?

Southwest Airlines, Delta and three other airlines fly from Boston to St Louis hourly. Alternatively, you can take a bus from Boston to St Louis via Newark in around 28h 11m.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Boston to St. Louis
Ave. Duration
3h 6m
When
Every day
Estimated price
$75 - $280
Flights from Boston to St. Louis via Chicago Midway
Ave. Duration
4h 56m
When
Every day
Estimated price
$80 - $290
Flights from Boston to St. Louis via Baltimore
Ave. Duration
5h 6m
When
Monday, Thursday, Friday, Saturday and Sunday
Estimated price
$80 - $290
Flights from Hartford to St. Louis
Ave. Duration
2h 40m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$95 - $330
Flights from Hartford to St. Louis via Chicago Midway
Ave. Duration
4h 25m
When
Monday, Thursday, Friday and Sunday
Estimated price
$95 - $340
Flights from Hartford to St. Louis via Baltimore
Ave. Duration
4h 48m
When
Every day
Estimated price
$95 - $340
Delta
Website
delta.com
Flights from Boston to St. Louis via Detroit
Ave. Duration
4h 47m
When
Every day
Estimated price
$50 - $360
Flights from Hartford to St. Louis via Detroit
Ave. Duration
4h 33m
When
Every day
Estimated price
$60 - $430
Flights from Hartford to St. Louis via Atlanta
Ave. Duration
5h 14m
When
Every day
Estimated price
$80 - $480
United Airlines
Website
united.com
Flights from Boston to St. Louis via Washington Dulles
Ave. Duration
4h 54m
When
Every day
Estimated price
$95 - $400
Flights from Boston to St. Louis via Chicago O'Hare
Ave. Duration
5h 11m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$95 - $400
Flights from Boston to St. Louis via Newark
Ave. Duration
5h 13m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$95 - $400
Flights from Hartford to St. Louis via Toronto
Ave. Duration
4h 37m
When
Every day
Estimated price
$150 - $700
Flights from Hartford to St. Louis via Chicago O'Hare
Ave. Duration
4h 56m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $450
American Airlines
Website
aa.com
Flights from Hartford to St. Louis via Philadelphia
Ave. Duration
5h 4m
When
Every day
Estimated price
$220 - $450
Flights from Hartford to St. Louis via Charlotte
Ave. Duration
5h 11m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $450
Air Canada
Website
aircanada.com
Flights from Hartford to St. Louis via Toronto
Ave. Duration
4h 37m
When
Every day
Estimated price
$150 - $700
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Boston South Station to Chicago Union Station
Ave. Duration
22h
Frequency
Once daily
Estimated price
$100 - $150
Schedules at
amtrak.com
Coach Seat
$100 - $150
Premium
$330 - $460
Flexi Coach Seat
$200 - $310
Business Seat
$220 - $310
Train from Chicago Union Station to St. Louis
Ave. Duration
5h 30m
Frequency
4 times a day
Estimated price
$40 - $60
Schedules at
amtrak.com
Coach Seat
$40 - $60
Premium
$210 - $300
Flexi Coach Seat
$75 - $110
Business Seat
$75 - $110
Bus operators
Peter Pan Bus Lines
Phone
1-800-343-9999
Website
peterpanbus.com
Bus from South Station, Boston, MA to Union Station, Hartford, CT
Ave. Duration
2h 20m
Frequency
Every 2 hours
Estimated price
$21 - $30
Website
peterpanbus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Boston to Hartford
Ave. Duration
1h 50m
Frequency
4 times a day
Estimated price
$17 - $24
Website
greyhound.com
Economy
$17 - $24
Flexible
$35 - $50
Bus from Boston to Newark
Ave. Duration
5h 15m
Frequency
5 times a week
Estimated price
$28 - $40
Website
greyhound.com
Economy
$28 - $40
Flexible
$50 - $75
Bus from Newark to St Louis
Ave. Duration
22h 20m
Frequency
Twice daily
Estimated price
$100 - $140
Website
greyhound.com
Economy
$100 - $140
Flexible
$140 - $210
Boltbus
Phone
+1 1-877-265-8287
Website
boltbus.com
Bus from Boston South Buses to Newark Penn Station
Ave. Duration
4h 51m
Frequency
Twice daily
Estimated price
$20 - $35
Website
boltbus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from Boston Airport to St. Louis Airport is the direct flight which takes 3h.

Search flights

Boston to St Louis bus services, operated by Greyhound USA, arrive at St Louis station.

More details

St Louis is 1h behind Boston. It is currently 4:43 PM in Boston and 3:43 PM in St Louis.

Boston to St Louis train services, operated by Amtrak, arrive at St. Louis station.

More details

Yes, the driving distance between Boston to St Louis is 1184 miles. It takes approximately 19h 41m to drive from Boston to St Louis.

Get driving directions

Delta, United Airlines and Southwest Airlines offer flights from Boston Airport to St. Louis Airport.

Search flights

Book your Boston to St Louis train tickets online with Omio.

Search and book

There are 398+ hotels available in St Louis. Prices start at $100 USD per night.

More details

The best way to get from Boston to Boston Airport is to bus which takes 0 min and costs $1 - $13.

More details