The average train between Slough and Macclesfield takes 3h 10m and the fastest train takes 2h 36m. There is a train service every few hours from Slough to Macclesfield. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Slough and Macclesfield. The earliest departure is at 5:52 AM in the morning, and the last departure from Slough is at 11:21 PM which arrives into Macclesfield at 7:59 AM. All services require a transfer at Tottenham Court Road Station and take an average of 3h 10m. The schedules shown below are for the next available departures.
Arrives next day


3h 20m • 2 changes
Arrives next day


8h 38m • 2 changes


2h 48m • 2 changes


2h 49m • 2 changes


2h 49m • 2 changes


2h 49m • 2 changes


2h 49m • 2 changes


2h 51m • 2 changes


2h 51m • 2 changes


2h 51m • 2 changes


3h 23m • 2 changes


3h 4m • 2 changes


2h 51m • 2 changes


2h 51m • 2 changes
Want to know about travelling from Slough to Macclesfield? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Slough to Macclesfield. However, there are services departing from Slough station and arriving at Macclesfield station via Tottenham Court Rd. The journey, including transfers, takes approximately 3h 10m.
Slough to Macclesfield train services, operated by Elizabeth Line (TfL), depart from Slough station.
Slough to Macclesfield train services, operated by Elizabeth Line (TfL), arrive at Macclesfield station.
Book your Slough to Macclesfield train tickets online with Elizabeth Line (TfL), London Underground (Tube) and Avanti West Coast.
The distance between Slough and Macclesfield is 220.6 km. The road distance is 300 km.
You can take a train from Slough to Macclesfield via Tottenham Court Road Station, Tottenham Court Road station, Euston station, and London Euston in around 3h 16m.