The average train between Siena and Lyon takes 12h 51m and the fastest train takes 10h 52m. The train service runs several times per day from Siena to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Siena and Lyon. The earliest departure is at 7:02 AM in the morning, and the last departure from Siena is at 6:18 PM which arrives into Lyon at 1:03 PM. All services require a transfer at Firenze S.M.N. and take an average of 12h 51m. The schedules shown below are for the next available departures.



11h 8m • 3 changes



11h 14m • 3 changes



10h 52m • 3 changes
Arrives next day



17h 56m • 3 changes



10h 55m • 3 changes



11h 23m • 3 changes
Arrives next day



18h 45m • 3 changes



11h 8m • 3 changes



11h 14m • 3 changes



10h 52m • 3 changes
Arrives next day



18h 45m • 3 changes



11h 8m • 3 changes



11h 14m • 3 changes



10h 52m • 3 changes
Arrives next day



18h 45m • 3 changes
Want to know about travelling from Siena to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Siena to Lyon. However, there are services departing from Siena station and arriving at Lyon station via Firenze S.M.N.. The journey, including transfers, takes approximately 12h 51m.
Siena to Lyon train services, operated by Trenitalia, depart from Siena station.
Siena to Lyon train services, operated by Trenitalia, arrive at Lyon Part Dieu station.
Book your Siena to Lyon train tickets online with Trenitalia, Trenitalia Frecce and 2 other operators.
The distance between Siena and Lyon is 580.4 km. The road distance is 842 km.
You can take a train from Siena to Lyon Part Dieu via Firenze S.M.N., Torino Porta Susa, and Chambery Challes Les Eaux in around 10h 21m.