The average train between Rome and Desio takes 4h 20m and the fastest train takes 3h 41m. There is a train service every few hours from Rome to Desio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Rome and Desio. The earliest departure is at 5:40 AM in the morning, and the last departure from Rome is at 8:05 PM which arrives into Desio at 6:05 AM. All services require a transfer at Milano Centrale and take an average of 4h 20m. The schedules shown below are for the next available departures.


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3h 55m • 2 changes


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3h 46m • 2 changes


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Want to know about travelling from Rome to Desio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Desio. However, there are services departing from Rome station and arriving at Desio station via Milano Centrale. The journey, including transfers, takes approximately 4h 20m.
Rome to Desio train services, operated by ItaloTreno, depart from Roma Termini station.
Rome to Desio train services, operated by ItaloTreno, arrive at Milano Centrale station.
The distance between Rome and Desio is 490.8 km. The road distance is 599 km.
ItaloTreno operates a train from Roma Termini to Milano Centrale every 30 minutes. Tickets cost €75–150 and the journey takes 3h 5m.