The train between Rome and Desio takes 4h 40m. The train service runs several times per day from Rome to Desio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 5 times a day between Rome and Desio. The earliest departure is at 7:25 AM in the morning, and the last departure from Rome is at 6:25 PM which arrives into Desio at 11:05 PM. All services require a transfer, and take on average 4h 40m. The schedules shown below are for the next available departures.

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Want to know about travelling from Rome to Desio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Rome to Desio. However, there are services departing from Rome station and arriving at Desio station via Milano P.Garibaldi. The journey, including transfers, takes approximately 4h 40m.
Rome to Desio train services, operated by Trenitalia Frecce, depart from Roma Termini station.
Rome to Desio train services, operated by Trenitalia Frecce, arrive at Milano P.Garibaldi station.
Book your Rome to Desio train tickets online with Trenitalia Frecce and Trenord.
The distance between Rome and Desio is 490.8 km. The road distance is 585 km.
Trenitalia Frecce operates a train from Roma Termini to Milano P.Garibaldi every 3 hours. Tickets cost €80–170 and the journey takes 3h 47m.