Train Prestwick to Manchester from £114 | Tickets & Timetables

Trip Overview

The average train between Prestwick and Manchester takes 4h 41m and the fastest train takes 4h 3m. There is a train service every few hours from Prestwick to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 41m
Duration: 259 mi
Distance: £114
Average price: Hourly
Frequency

Train

best

Take the train from Prestwick Town to Glasgow Centraltrain
Take the train from Glasgow Central to Prestontrain
Take the train from Preston to Manchester Piccadillytrain

4h 37m

£73–173

Prestwick to Manchester train times

Trains run hourly between Prestwick and Manchester. The earliest departure is at 5:20 AM in the morning, and the last departure from Prestwick is at 11:10 PM which arrives into Manchester at 7:57 AM. All services require a transfer at Glasgow Central and take an average of 4h 41m. The schedules shown below are for the next available departures.

Departing Sunday, May 17, 2026

5:20 PM → 9:54 PM
4h 34m • 2 changes
5:50 PM → 10:56 PM
5h 5m • 2 changes
7:20 PM → 11:23 PM
4h 3m • 2 changes
11:05 PM → 7:57 AM
Arrives next day
8h 52m • 2 changes

Departing Monday, May 18, 2026

5:20 AM → 9:58 AM
4h 37m • 2 changes
6:08 AM → 10:26 AM
4h 17m • 2 changes
6:40 AM → 10:58 AM
4h 17m • 2 changes
7:10 AM → 11:15 AM
4h 4m • 2 changes
Show more

Departing Tuesday, May 19, 2026

5:20 AM → 9:58 AM
4h 37m • 2 changes
6:08 AM → 10:26 AM
4h 17m • 2 changes
6:40 AM → 10:58 AM
4h 17m • 2 changes
7:10 AM → 11:15 AM
4h 4m • 2 changes
Show more

Departing Wednesday, May 20, 2026

5:20 AM → 9:58 AM
4h 37m • 2 changes
6:08 AM → 10:26 AM
4h 17m • 2 changes

Frequently asked questions

Want to know about travelling from Prestwick to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.