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Prestwick to Manchester buses

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Trip Overview

The average bus between Prestwick and Manchester takes 5h 59m and the fastest bus takes 5h 20m. The bus service runs several times per day from Prestwick to Manchester. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

5h 59m
Duration
245 mi
Distance
£41
Average price
Twice daily
Frequency

Prestwick to Manchester bus times

Buses run twice daily between Prestwick and Manchester. The earliest departure is at 8:55 AM in the morning, and the last departure from Prestwick is at 9:20 PM which arrives into Manchester at 2:40 AM. All services require a transfer, and take on average 5h 59m. The schedules shown below are for the next available departures.

Departing Sunday, November 15, 2026

  •  → 

    Stagecoach West ScotlandFlixBus6h 5m • 1 change
  •  → 

    Arrives next day

    Stagecoach West ScotlandFlixBus5h 50m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Stagecoach West ScotlandFlixBus6h 25m • 1 change
  •  → 

    Arrives next day

    Stagecoach West ScotlandFlixBus5h 50m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Stagecoach West ScotlandFlixBus6h 25m • 1 change
  •  → 

    Arrives next day

    Stagecoach West ScotlandFlixBus5h 50m • 1 change

Departing Wednesday, November 18, 2026

  •  → 

    Stagecoach West ScotlandFlixBus6h 25m • 1 change
  •  → 

    Arrives next day

    Stagecoach West ScotlandFlixBus5h 50m • 1 change

Departing Thursday, November 19, 2026

  •  → 

    Stagecoach West ScotlandFlixBus6h 25m • 1 change
  •  → 

    Arrives next day

    Stagecoach West ScotlandFlixBus5h 50m • 1 change

Departing Friday, November 20, 2026

  •  → 

    Stagecoach West ScotlandFlixBus6h 25m • 1 change
  •  → 

    Arrives next day

    Stagecoach West ScotlandFlixBus5h 20m • 1 change

Departing Saturday, November 21, 2026

  •  → 

    Stagecoach West ScotlandFlixBus5h 55m • 1 change
  •  → 

    Arrives next day

    Stagecoach West ScotlandFlixBus5h 20m • 1 change

Frequently asked questions

Want to know about travelling from Prestwick to Manchester? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Prestwick to Manchester.ExpandLaunch map view
  • Distance: 245.2 mi
  • Duration: 5h 59m

What companies run services between Prestwick, Scotland and Manchester, England?

You can take a bus from Station Road to Shudehill Interchange via Buchanan Bus Station in around 5h 28m.

Operators