The average train between Prestwich and Holyhead takes 3h 53m and the fastest train takes 3h 18m. There is a train service every few hours from Prestwich to Holyhead. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Prestwich and Holyhead. The earliest departure is at 12:50 AM at night, and the last departure from Prestwich is at 11:50 PM which arrives into Holyhead at 8:51 AM. All services require a transfer at Piccadilly and take an average of 3h 53m. The schedules shown below are for the next available departures.

3h 35m • 1 change

3h 43m • 1 change

3h 36m • 1 change
Arrives next day

3h 44m • 1 change

3h 37m • 1 change

3h 41m • 1 change

3h 35m • 1 change

3h 35m • 1 change

3h 37m • 1 change

3h 41m • 1 change

3h 35m • 1 change

3h 35m • 1 change

8h 1m • 1 change

3h 37m • 1 change

3h 41m • 1 change

3h 35m • 1 change
Want to know about travelling from Prestwich to Holyhead? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Prestwich to Holyhead. However, there are services departing from Prestwich station and arriving at Holyhead station via Holyhead. The journey, including transfers, takes approximately 3h 53m.
Prestwich to Holyhead train services, operated by Metrolink, depart from Manchester Piccadilly station.
Prestwich to Holyhead train services, operated by Metrolink, arrive at Holyhead station.
The distance between Prestwich and Holyhead is 157.7 km. The road distance is 208 km.
Transport for Wales operates a train from Manchester Piccadilly to Holyhead hourly. Tickets cost £45–85 and the journey takes 2h 56m.