The average train between Preston and Middlesex takes 3h 23m and the fastest train takes 2h 45m. There is a train service every few hours from Preston to Middlesex. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Preston and Middlesex. The earliest departure is at 3:15 AM at night, and the last departure from Preston is at 9:18 PM which arrives into Middlesex at 5:47 AM. All services require a transfer, and take on average 3h 23m. The schedules shown below are for the next available departures.

4h 16m • 1 change

3h 58m • 1 change

2h 58m • 1 change

2h 48m • 1 change

4h 16m • 1 change

3h 58m • 1 change

2h 58m • 1 change

2h 48m • 1 change

4h 16m • 1 change

4h • 1 change

2h 58m • 1 change

3h 1m • 1 change
Want to know about travelling from Preston to Middlesex? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Preston to Middlesex. However, there are services departing from Preston station and arriving at Middlesex station via London Euston. The journey, including transfers, takes approximately 3h 23m.
Preston to Middlesex train services, operated by Caledonian Sleeper, depart from Preston station.
Preston to Middlesex train services, operated by Caledonian Sleeper, arrive at London Euston station.
Book your Preston to Middlesex train tickets online with Caledonian Sleeper, London Overground and Avanti West Coast.
The distance between Preston and Middlesex is 297.5 km. The road distance is 344 km.
Avanti West Coast operates a train from Preston to London Euston hourly. Tickets cost £75–130 and the journey takes 2h 15m. Caledonian Sleeper also services this route twice daily.